Thomas R. Malek, et.al., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2., Immunity, 2002, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/12196288

Thomas R. Malek, et.al., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2., Immunity, 2002, 17

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0000691B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• decreased T cell proliferation_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0005095C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• increased susceptibility to autoimmune disorder_Il2<tm1Hor>/Il2<tm1Hor>
  http://metadb.riken.jp/0005350B6129P2Il2tm1HorJIl2tm1HorIl2tm1HorIl2tm1Hor
• abnormal marginal zone B cell morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0008180C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal T cell clonal deletion_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0005002D2129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• decreased regulatory T cell number_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0004974B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• enlarged lymph nodes_Il2<tm1Hor>/Il2<tm1Hor>
  http://metadb.riken.jp/0000702B6129P2Il2tm1HorJIl2tm1HorIl2tm1HorIl2tm1Hor
• liver inflammation_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0001860C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal spleen periarteriolar lymphoid sheath morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002358B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• enlarged lymph nodes_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0000702C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal response to transplant_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0005671B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal immune system organ morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002722C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal spleen periarteriolar lymphoid sheath morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002358C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• increased anti-double stranded DNA antibody level_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0004762B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal lymphocyte morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002619B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal response to transplant_Il2<tm1Hor>/Il2<tm1Hor>
  http://metadb.riken.jp/0005671B6129P2Il2tm1HorJIl2tm1HorIl2tm1HorIl2tm1Hor
• abnormal T cell activation_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0001828C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• increased anti-double stranded DNA antibody level_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0004762C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• premature death_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002083C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• decreased T cell proliferation_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0005095B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal lymphocyte morphology_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0002619C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• enlarged lymph nodes_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0000702B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• decreased CD8-positive, alpha-beta T cell number_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0008079C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• increased susceptibility to autoimmune hemolytic anemia_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0004827C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal T cell activation_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0001828B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• decreased regulatory T cell number_Il2<tm1Hor>/Il2<tm1Hor>
  http://metadb.riken.jp/0004974B6129P2Il2tm1HorJIl2tm1HorIl2tm1HorIl2tm1Hor
• enlarged spleen_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0000691C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• increased susceptibility to autoimmune hemolytic anemia_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0004827B6129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak
• abnormal T cell clonal deletion_Il2rb<tm1Mak>/Il2rb<tm1Mak>
  http://metadb.riken.jp/0005002C129Il2rbtm1MakIl2rbtm1MakIl2rbtm1MakIl2rbtm1Mak

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• liver inflammation in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012980
• abnormal T cell activation in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010400
• decreased T cell proliferation in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013010
• abnormal spleen periarteriolar lymphoid sheath morphology in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012986
• abnormal marginal zone B cell morphology in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001244
• enlarged lymph nodes in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010399
• enlarged spleen in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012966
• abnormal T cell clonal deletion in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001233
• abnormal lymphocyte morphology in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001227
• decreased regulatory T cell number in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001232
• abnormal response to transplant in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001237
• increased susceptibility to autoimmune hemolytic anemia in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013001
• decreased T cell proliferation in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001236
• abnormal spleen periarteriolar lymphoid sheath morphology in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001225
• abnormal lymphocyte morphology in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012994
• abnormal immune system organ morphology in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001228
• premature death in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012983
• increased anti-double stranded DNA antibody level in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012999
• decreased CD8-positive, alpha-beta T cell number in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013024
• decreased regulatory T cell number in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013003
• decreased CD8-positive, alpha-beta T cell number in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001242
• abnormal marginal zone B cell morphology in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013027
• increased susceptibility to autoimmune hemolytic anemia in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010402
• enlarged spleen in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010398
• enlarged lymph nodes in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012968
• abnormal immune system organ morphology in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012995
• liver inflammation in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001223
• premature death in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010401
• increased anti-double stranded DNA antibody level in RBRC00756
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001230
• abnormal response to transplant in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013015
• abnormal T cell activation in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1012978
• abnormal T cell clonal deletion in RBRC00522
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1013004