Dimitris. Kontoyiannis, et.al., Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease., The Journal of experimental medicine, 2002, 196

http://rdf.ncbi.nlm.nih.gov/pubmed/12486099

Dimitris. Kontoyiannis, et.al., Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease., The Journal of experimental medicine, 2002, 196

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Tnf<tm2.1Gkl>/Tnf<+>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0001263I129P2OlaHsd129SSvEv129S6SvEvTacC57BL6JTnftm21GklTnfLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm21GklTnf
• small intestinal inflammation_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• decreased apoptosis_Mapkapk2<tm1Mgl>/Mapkapk2<tm1Mgl>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0006043I129P2OlaHsd129SSvEvC57BL6JMapkapk2tm1MglMapkapk2tm1MglTnftm2GklTnfTnftm2GklMapkapk2tm1MglTnf
• small intestinal inflammation_Tcrd<tm1Mom>/Tcrd<tm1Mom>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129P2OlaHsd129SSvEvC57BL6JTcrdtm1MomTcrdtm1MomTnftm2GklTnfTnfTnftm2GklTcrdtm1Mom
• small intestinal inflammation_Map3k8<tm1Pnt>/Map3k8<tm1Pnt>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129P2OlaHsd129SSvEvC57BL6JMap3k8tm1PntMap3k8tm1PntTnftm2GklTnfMap3k8tm1PntTnfTnftm2Gkl
• increased apoptosis_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0006042I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• increased apoptosis_Mapk9<tm1Flv>/Mapk9<tm1Flv>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0006042I129P2OlaHsd129SSvEvC57BL6JMapk9tm1FlvMapk9tm1FlvTnftm2GklTnfTnftm2GklMapk9tm1FlvTnf
• premature death_Cd4<tm1Mak>/Cd4<tm1Mak>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0002083I129SSvEv129S2SvPasC57BL6JCd4tm1MakCd4tm1MakTnftm2GklTnfTnfCd4tm1MakTnftm2Gkl
• abnormal response to transplant_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0005671I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• abnormal myelopoiesis_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0001601I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• weight loss_Tnf<tm2.1Gkl>/Tnf<tm2.1Gkl>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0001263I129P2OlaHsd129SSvEvC57BL6JTnftm21GklTnftm21GklLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Tnftm21Gkl
• small intestinal inflammation_Il12b<tm1Jm>/Il12b<tm1Jm>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEv129S1SvC57BL6JIl12btm1JmIl12btm1JmTnftm2GklTnfTnftm2GklIl12btm1JmTnf
• increased CD8-positive, alpha-beta T cell number_Map3k8<tm1Pnt>/Map3k8<tm1Pnt>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0008078I129P2OlaHsd129SSvEvC57BL6JMap3k8tm1PntMap3k8tm1PntTnftm2GklTnfMap3k8tm1PntTnfTnftm2Gkl
• abnormal cytotoxic T cell physiology_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0005078I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• increased single-positive T cell number_Map3k8<tm1Pnt>/Map3k8<tm1Pnt>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0008082I129P2OlaHsd129SSvEvC57BL6JMap3k8tm1PntMap3k8tm1PntTnftm2GklTnfMap3k8tm1PntTnfTnftm2Gkl
• small intestinal inflammation_Ifng<tm1Ts>/Ifng<tm1Ts>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEv129S7SvEvBrdC57BL6JIfngtm1TsIfngtm1TsTnftm2GklTnfTnftm2GklIfngtm1TsTnf
• small intestinal inflammation_B2m<tm1Jae>/B2m<tm1Jae>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEv129S2SvPasC57BL6JB2mtm1JaeB2mtm1JaeTnftm2GklTnfTnftm2GklTnfB2mtm1Jae
• small intestinal inflammation_Mapk9<tm1Flv>/Mapk9<tm1Flv>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129P2OlaHsd129SSvEvC57BL6JMapk9tm1FlvMapk9tm1FlvTnftm2GklTnfTnftm2GklMapk9tm1FlvTnf
• granulomatous inflammation_Mapkapk2<tm1Mgl>/Mapkapk2<tm1Mgl>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0002500I129P2OlaHsd129SSvEvC57BL6JMapkapk2tm1MglMapkapk2tm1MglTnftm2GklTnfTnftm2GklMapkapk2tm1MglTnf
• small intestinal inflammation_Mapkapk2<tm1Mgl>/Mapkapk2<tm1Mgl>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129P2OlaHsd129SSvEvC57BL6JMapkapk2tm1MglMapkapk2tm1MglTnftm2GklTnfTnftm2GklMapkapk2tm1MglTnf
• small intestinal inflammation_Cd4<tm1Mak>/Cd4<tm1Mak>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEv129S2SvPasC57BL6JCd4tm1MakCd4tm1MakTnftm2GklTnfTnfCd4tm1MakTnftm2Gkl
• premature death_Mapkapk2<tm1Mgl>/Mapkapk2<tm1Mgl>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0002083I129P2OlaHsd129SSvEvC57BL6JMapkapk2tm1MglMapkapk2tm1MglTnftm2GklTnfTnftm2GklMapkapk2tm1MglTnf
• increased CD8-positive, alpha-beta T cell number_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0008078I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• small intestinal inflammation_Ighm<tm1Cgn>/Ighm<tm1Cgn>,Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0003306I129SSvEv129S2SvPasC57BL6JIghmtm1CgnIghmtm1CgnTnftm2GklTnfTnftm2GklTnfIghmtm1Cgn
• enlarged spleen_Tnf<tm2Gkl>/Tnf<+>
  http://metadb.riken.jp/0000691I129SSvEvC57BL6JTnftm2GklTnfTnfTnftm2Gkl
• small intestinal inflammation_Tnf<tm2.1Gkl>/Tnf<tm2.1Gkl>,Tg(Lck-cre)I57Jxm/0
  http://metadb.riken.jp/0003306I129SSvEvICRTnftm21GklTnftm21GklTgLckcreI57Jxm0Tnftm21GklTgLckcreI57Jxm