Eunice Y. Lee, et.al., E2F4 loss suppresses tumorigenesis in Rb mutant mice., Cancer cell, 2002, 2

http://rdf.ncbi.nlm.nih.gov/pubmed/12498715

Eunice Y. Lee, et.al., E2F4 loss suppresses tumorigenesis in Rb mutant mice., Cancer cell, 2002, 2

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cell proliferation_Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0000351I129S2SvPasC57BL6Rb1tm1TyjRb1tm1TyjRb1tm1Tyj
• premature death_E2f4<tm1Lees>/E2f4<+>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6E2f4tm1LeesE2f4Rb1tm1TyjRb1E2f4E2f4tm1LeesRb1tm1TyjRb1
• increased pituitary gland tumor incidence_E2f4<tm1Lees>/E2f4<+>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010320I129S2SvPasC57BL6E2f4tm1LeesE2f4Rb1tm1TyjRb1E2f4E2f4tm1LeesRb1tm1TyjRb1
• increased thyroid tumor incidence_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010316I129S2SvPasC57BL6Rb1tm1TyjRb1Rb1tm1TyjRb1
• increased pituitary gland tumor incidence_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010320I129S2SvPasC57BL6Rb1tm1TyjRb1Rb1tm1TyjRb1
• lethality throughout fetal growth and development, complete penetrance_Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0011099I129S2SvPasC57BL6Rb1tm1TyjRb1tm1TyjRb1tm1Tyj
• decreased tumor incidence_E2f4<tm1Lees>/E2f4<tm1Lees>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002052I129S2SvPasC57BL6E2f4tm1LeesE2f4tm1LeesRb1tm1TyjRb1E2f4tm1LeesRb1tm1TyjRb1
• premature death_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Rb1tm1TyjRb1Rb1tm1TyjRb1
• increased thyroid tumor incidence_E2f4<tm1Lees>/E2f4<+>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010316I129S2SvPasC57BL6E2f4tm1LeesE2f4Rb1tm1TyjRb1E2f4E2f4tm1LeesRb1tm1TyjRb1
• increased susceptibility to infection_E2f4<tm1Lees>/E2f4<tm1Lees>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002406I129S2SvPasC57BL6E2f4tm1LeesE2f4tm1LeesRb1tm1TyjRb1E2f4tm1LeesRb1tm1TyjRb1
• premature death_E2f4<tm1Lees>/E2f4<tm1Lees>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6E2f4tm1LeesE2f4tm1LeesRb1tm1TyjRb1E2f4tm1LeesRb1tm1TyjRb1