Palle G. Laustsen, et.al., Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice., Genes & development, 2002, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/12502742

Palle G. Laustsen, et.al., Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice., Genes & development, 2002, 16

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal gonadal fat pad morphology_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005335I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• decreased circulating free fatty acid level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0002702I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• decreased white adipose tissue amount_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0001783I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• decreased circulating triglyceride level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0002644I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• postnatal growth retardation_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0001732I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• increased pancreatic beta cell mass_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0009113I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• insulin resistance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Y
  http://metadb.riken.jp/0005331I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdYIrs1tm1JosIrs4tm1Lhd
• increased circulating insulin level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Y
  http://metadb.riken.jp/0002079I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdYIrs1tm1JosIrs4tm1Lhd
• pancreatic islet hyperplasia_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005491I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• decreased circulating leptin level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005668I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• impaired glucose tolerance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Y
  http://metadb.riken.jp/0005293I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdYIrs1tm1JosIrs4tm1Lhd
• impaired glucose tolerance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Irs4<tm1Lhd>
  http://metadb.riken.jp/0005293I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdIrs4tm1LhdIrs4tm1LhdIrs1tm1Jos
• decreased triglyceride level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005318I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• hyperglycemia_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0001559I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• increased circulating insulin level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Irs4<tm1Lhd>
  http://metadb.riken.jp/0002079I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdIrs4tm1LhdIrs4tm1LhdIrs1tm1Jos
• insulin resistance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005331I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• postnatal growth retardation_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Y
  http://metadb.riken.jp/0001732I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdYIrs1tm1JosIrs4tm1Lhd
• postnatal growth retardation_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Irs4<tm1Lhd>
  http://metadb.riken.jp/0001732I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdIrs4tm1LhdIrs4tm1LhdIrs1tm1Jos
• insulin resistance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs4<tm1Lhd>/Irs4<tm1Lhd>
  http://metadb.riken.jp/0005331I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs4tm1LhdIrs4tm1LhdIrs4tm1LhdIrs1tm1Jos
• increased circulating insulin level_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0002079I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd
• postnatal growth retardation_Irs1<tm1Jos>/Irs1<tm1Jos>
  http://metadb.riken.jp/0001732I129S2SvPasC57BL6Irs1tm1JosIrs1tm1JosIrs1tm1Jos
• impaired glucose tolerance_Irs1<tm1Jos>/Irs1<tm1Jos>,Irs3<tm1Lhd>/Irs3<tm1Lhd>
  http://metadb.riken.jp/0005293I129S2SvPas129S4SvJaeC57BL6Irs1tm1JosIrs1tm1JosIrs3tm1LhdIrs3tm1LhdIrs1tm1JosIrs3tm1Lhd

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD11169
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD11169
• CD30022
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD30022