Leslie F. Jackson, et.al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling., The EMBO journal, 2003, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/12773386

Leslie F. Jackson, et.al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling., The EMBO journal, 2003, 22

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Btc<tm1Dcl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2665044
• Hbegf<tm1Dcl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2665039

class

http://purl.org/net/cito/citesAsAuthority

• Btc<tm1Dcl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2665044
• Hbegf<tm1Dcl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2665039

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal semilunar valve morphology_Adam17<tm1Imx>/Adam17<tm1Imx>
  http://metadb.riken.jp/0002746I129C57BL6JAdam17tm1ImxAdam17tm1ImxAdam17tm1Imx
• pulmonary valve stenosis_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0006128I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• dilated heart left atrium_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0004063I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• ectopic cartilage_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0003869I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal semilunar valve morphology_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002746I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• ectopic cartilage_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0003869I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• postnatal lethality_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002082I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• aortic valve stenosis_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0006117I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal atrioventricular valve morphology_Adam17<tm1Imx>/Adam17<tm1Imx>
  http://metadb.riken.jp/0002745I129C57BL6JAdam17tm1ImxAdam17tm1ImxAdam17tm1Imx
• pulmonary hypoplasia_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0001178I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• decreased ventricle muscle contractility_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0005598I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• no abnormal phenotype detected_Btc<tm1Dcl>/Btc<tm1Dcl>
  http://metadb.riken.jp/0002169I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclBtctm1Dcl
• enlarged aortic valve_Adam17<tm1Imx>/Adam17<tm1Imx>
  http://metadb.riken.jp/0010591I129C57BL6JAdam17tm1ImxAdam17tm1ImxAdam17tm1Imx
• enlarged pulmonary valve_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0010600I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• premature death_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• enlarged heart_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• enlarged aortic valve_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0010591I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• abnormal pulmonary alveolus morphology_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002270I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• cardiac fibrosis_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0003141I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• abnormal pulmonary valve morphology_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002748I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• premature death_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal type II pneumocyte morphology_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002275I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• aorta dilation_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0010574I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• decreased body weight_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• increased heart weight_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002833I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• impaired lung alveolus development_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0006027I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal atrioventricular valve morphology_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002745I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• enlarged aortic valve_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0010591I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal atrial thrombosis_Btc<tm1Dcl>/Btc<tm1Dcl>,Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0001855I129S1Sv129X1SvJC57BL6JBtctm1DclBtctm1DclHbegftm1DclHbegftm1DclHbegftm1DclBtctm1Dcl
• abnormal semilunar valve morphology_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002746I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• abnormal atrioventricular valve morphology_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0002745I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl
• decreased ventricle muscle contractility_Hbegf<tm1Dcl>/Hbegf<tm1Dcl>
  http://metadb.riken.jp/0005598I129S1Sv129X1SvJC57BL6JHbegftm1DclHbegftm1DclHbegftm1Dcl