Yi Lisa. Lyu, et.al., Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100

http://rdf.ncbi.nlm.nih.gov/pubmed/12773624

Yi Lisa. Lyu, et.al., Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Top2b<tm2Jcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3521850
• Top2b<tm2.1Jcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3521923

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal hippocampus pyramidal cell layer_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0008284I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• abnormal motor capabilities/coordination/movement_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0002066I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• decreased brain size_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0000774I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• abnormal stratification in cerebral cortex_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0000790I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• abnormal neuronal migration_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0006009I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• absent subplate_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0008443I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• disorganized cortical plate_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0008442I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• abnormal hippocampus granule cell layer_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0008285I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• neonatal lethality, complete penetrance_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0011087I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• respiratory failure_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0001953I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• small olfactory bulb_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0002741I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• abnormal embryonic/fetal subventricular zone morphology_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0004274I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• abnormal spine curvature_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0004174I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• atelectasis_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0001177I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• respiratory failure_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0001953I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• no abnormal phenotype detected_Top2b<tm2Jcw>/Top2b<tm2Jcw>
  http://metadb.riken.jp/0002169129S6SvEvTacTop2btm2JcwTop2btm2JcwTop2btm2JcwTop2btm2Jcw
• abnormal cerebral cortex morphology_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000788I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm
• abnormal telencephalon development_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0000934I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• small olfactory bulb_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0002741I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• neonatal lethality, complete penetrance_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0011087I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• decreased body size_Top2b<tm2.1Jcw>/Top2b<tm2.1Jcw>
  http://metadb.riken.jp/0001265I129S4SvJae129S6SvEvTacTop2btm21JcwTop2btm21JcwTop2btm21Jcw
• abnormal hippocampus morphology_Top2b<tm2Jcw>/Top2b<tm2.1Jcw>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0000807I129S4SvJae129S6SvEvTac129X1SvJTop2btm2JcwTop2btm21JcwFoxg1tm1creSkmFoxg1Top2btm21JcwFoxg1Top2btm2JcwFoxg1tm1creSkm

class

http://purl.org/net/cito/citesAsAuthority

• Top2b<tm2Jcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3521850
• Top2b<tm2.1Jcw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3521923