Markus. Missler, et.al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis., Nature, 2003, 423

http://rdf.ncbi.nlm.nih.gov/pubmed/12827191

Markus. Missler, et.al., Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis., Nature, 2003, 423

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Nrxn2<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3042719
• Nrxn3<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3042720

class

http://purl.org/net/cito/citesAsAuthority

• Nrxn2<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3042719
• Nrxn3<tm1Sud>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3042720

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• reduced AMPA-mediated synaptic currents_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0011003I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• decreased CNS synapse formation_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>
  http://metadb.riken.jp/0004998I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn1tm1SudNrxn2tm1Sud
• abnormal paired-pulse inhibition_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0004807I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• decreased excitatory postsynaptic current amplitude_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0011270I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• neonatal lethality, complete penetrance_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0011087I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• postnatal lethality, incomplete penetrance_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>
  http://metadb.riken.jp/0011086I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn1tm1SudNrxn2tm1Sud
• abnormal GABA-mediated receptor currents_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0004008I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• postnatal lethality, incomplete penetrance_Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0011086I129C57BL6Nrxn3tm1SudNrxn3tm1SudNrxn3tm1Sud
• respiratory distress_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>
  http://metadb.riken.jp/0001954I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn1tm1SudNrxn2tm1Sud
• postnatal lethality, incomplete penetrance_Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0011086I129C57BL6Nrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn3tm1SudNrxn2tm1Sud
• decreased neurotransmitter release_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0003990I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• abnormal breathing pattern_Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0001951I129C57BL6Nrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn3tm1SudNrxn2tm1Sud
• abnormal synaptic depression_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0002915I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• abnormal excitatory postsynaptic currents_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>
  http://metadb.riken.jp/0002910I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn1tm1SudNrxn2tm1Sud
• decreased CNS synapse formation_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0004998I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• respiratory distress_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0001954I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• abnormal CNS synaptic transmission_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>
  http://metadb.riken.jp/0002206I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn1tm1SudNrxn2tm1Sud
• abnormal excitatory postsynaptic currents_Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0002910I129C57BL6Nrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn3tm1SudNrxn2tm1Sud
• abnormal CNS synaptic transmission_Nrxn1<tm1Sud>/Nrxn1<tm1Sud>,Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0002206I129C57BL6Nrxn1tm1SudNrxn1tm1SudNrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn1tm1SudNrxn2tm1SudNrxn3tm1Sud
• premature death_Nrxn2<tm1Sud>/Nrxn2<tm1Sud>,Nrxn3<tm1Sud>/Nrxn3<tm1Sud>
  http://metadb.riken.jp/0002083I129C57BL6Nrxn2tm1SudNrxn2tm1SudNrxn3tm1SudNrxn3tm1SudNrxn3tm1SudNrxn2tm1Sud

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00010
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00010