Leonard D. Shultz, et.al., NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment., Transplantation, 2003, 76

http://rdf.ncbi.nlm.nih.gov/pubmed/14557749

Leonard D. Shultz, et.al., NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment., Transplantation, 2003, 76

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thymus hypoplasia_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0001823NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal level of surface class II molecules_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0005042NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• spleen hypoplasia_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0000694NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• decreased mature B cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008211NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• increased macrophage cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0005425NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• increased immature B cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008214NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• increased granulocyte number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0000322NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• decreased CD4-positive, alpha beta T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0008075NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal spleen white pulp morphology_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002357NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal thymus cortex morphology_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002371NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• decreased immunoglobulin level_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0002460NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• increased T cell derived lymphoma incidence_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002024NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• decreased CD8-positive, alpha-beta T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0008079NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal lymph node cortex morphology_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002343NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• impaired natural killer cell mediated cytotoxicity_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005070NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• decreased mature B cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0008211NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• increased NK cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008044NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• decreased immunoglobulin level_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002460NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• premature death_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0002083NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal response to transplant_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0005671NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• abnormal level of surface class II molecules_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005042NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• impaired natural killer cell mediated cytotoxicity_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0005070NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• increased immature B cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0008214NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• decreased CD8-positive, alpha-beta T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008079NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• increased macrophage cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005425NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• spleen hypoplasia_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0000694NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• decreased CD4-positive, alpha beta T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0008075NOD129S7B6Rag1tm1MomRag1tm1MomRag1tm1MomRag1tm1Mom
• increased granulocyte number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0000322NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom
• increased NK cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Prf1<tm1Sdz>/Prf1<tm1Sdz>
  http://metadb.riken.jp/0008044NODCgRag1tm1MomPrf1tm1SdzSzRag1tm1MomRag1tm1MomPrf1tm1SdzPrf1tm1SdzPrf1tm1SdzRag1tm1Mom