Hua Shun. Li, et.al., Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis., Neuron, 2003, 40

http://rdf.ncbi.nlm.nih.gov/pubmed/14687546

Hua Shun. Li, et.al., Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis., Neuron, 2003, 40

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• circling_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001394I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• enlarged brain ventricles_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0011380I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal neuron differentiation_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0009937I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal forebrain morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000783I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal cortical marginal zone morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000792I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal brain ventricle morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000822I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal cerebral cortex morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000788I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• stereotypic behavior_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001408I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal thalamus morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000832I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• postnatal lethality, incomplete penetrance_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0011086I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• increased neuron apoptosis_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0003203I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• no abnormal phenotype detected_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>
  http://metadb.riken.jp/0002169I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbtm1YnjEmx1tm1creKrjEmx1
• abnormal lateral ventricle morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000823I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal hearing physiology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001963I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal embryonic neuroepithelium morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0004261I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• social withdrawal_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001361I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• male infertility_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001925I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal hippocampus morphology_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000807I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• female infertility_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001926I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• abnormal neuron specification_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0002948I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• decreased body size_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001265I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• absent corpus callosum_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0002196I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• ectopic cortical neuron_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0011724I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• sporadic seizures_Emx1<tm1(cre)Krj>/Emx1<+>,Numb<tm1Ynj>/Numb<tm1Ynj>,Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0000951I129S2SvPas129X1SvJCD1Emx1tm1creKrjEmx1Numbtm1YnjNumbtm1YnjNumbltm1WmzNumbltm1WmzNumbtm1YnjEmx1tm1creKrjNumbltm1WmzEmx1
• reduced female fertility_Numbl<tm1Wmz>/Numbl<tm1Wmz>
  http://metadb.riken.jp/0001923NSNumbltm1WmzNumbltm1WmzNumbltm1Wmz