Stefano. Casola, et.al., B cell receptor signal strength determines B cell fate., Nature immunology, 2004, 5

http://rdf.ncbi.nlm.nih.gov/pubmed/14758357

Stefano. Casola, et.al., B cell receptor signal strength determines B cell fate., Nature immunology, 2004, 5

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Igh<tm5.1Cgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037893
• Igh<tm5Cgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037892
• Tg(CD19-cre/ERT2)1Cgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037896

class

http://purl.org/net/cito/citesAsAuthority

• Igh<tm5.1Cgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037893
• Igh<tm5Cgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037892
• Tg(CD19-cre/ERT2)1Cgn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3037896

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased B cell number_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0005017BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• increased pro-B cell number_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0008186CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• abnormal Peyer's patch germinal center morphology_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0002391BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• decreased marginal zone B cell number_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008182BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• decreased immature B cell number_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008215BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent spleen germinal center_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008474BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent marginal zone B cells_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0008183CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• abnormal lymph node germinal center morphology_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008522BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent B-1 B cells_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008202BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent B-1b cells_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008204BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• abnormal B cell differentiation_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0002144CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• arrested B cell differentiation_Igh<tm5Cgn>/Igh<tm5Cgn>
  http://metadb.riken.jp/0001802IBALBcIghtm5CgnIghtm5CgnIghtm5Cgn
• abnormal Peyer's patch germinal center morphology_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0002391CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• abnormal mature B cell morphology_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008171BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• abnormal B cell differentiation_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0002144BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• abnormal B cell activation_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008217BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent B cells_Igh<tm5Cgn>/Igh<tm5Cgn>
  http://metadb.riken.jp/0008071IBALBcIghtm5CgnIghtm5CgnIghtm5Cgn
• increased B cell number_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0005014CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• abnormal mature B cell morphology_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0008171CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• absent follicular B cells_Igh<tm5Cgn>/Igh<tm5Cgn>,Tg(CD19-cre/ERT2)1Cgn/0
  http://metadb.riken.jp/0008175CCgIghtm5CgnTgCD19creERT21CgnIghtm5CgnIghtm5CgnTgCD19creERT21Cgn0Ightm5CgnTgCD19creERT21Cgn
• increased pro-B cell number_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008186BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• abnormal gut-associated lymphoid tissue morphology_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0002378BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn
• absent B-1a cells_Igh<tm5.1Cgn>/Igh<tm5.1Cgn>
  http://metadb.riken.jp/0008203BALBcIghtm51CgnIghtm51CgnIghtm51CgnIghtm51Cgn