Doan T. Le, et.al., Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder., Blood, 2004, 103

http://rdf.ncbi.nlm.nih.gov/pubmed/14982883

Doan T. Le, et.al., Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder., Blood, 2004, 103

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spleen morphology_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal myeloid leukocyte morphology_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008250I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal hematopoietic cell number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0011180I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• enlarged spleen_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal bone marrow cell morphology/development_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• increased neutrophil cell number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000219I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• hunched posture_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001505I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal myelopoiesis_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001601I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• disheveled coat_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001511I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal common myeloid progenitor cell morphology_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006410I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• increased leukocyte cell number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• increased granulocyte number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• increased lymphocyte cell number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005013I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• premature death_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• increased monocyte cell number_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal definitive hematopoiesis_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002123I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn
• abnormal gait_Nf1<tm1Par>/Nf1<tm1Par>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001406I129S1Sv129X1SvJC57BL6CBANf1tm1ParNf1tm1ParTgMx1cre1Cgn0Nf1tm1ParTgMx1cre1Cgn