Qian. Gao, et.al., Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101

http://rdf.ncbi.nlm.nih.gov/pubmed/15070774

Qian. Gao, et.al., Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• obese_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001261IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• impaired adaptive thermogenesis_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0011049IC57BLKSJLeprdbLeprdbLeprdb
• increased circulating corticosterone level_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001745IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating insulin level_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002079IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• hepatic steatosis_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002628IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• abnormal brown adipose tissue morphology_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002971IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• abnormal white adipose tissue morphology_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002970IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• decreased energy expenditure_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0004890IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• decreased food intake_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011940IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• hyperglycemia_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001559IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• anovulation_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0008869IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• short uterine horn_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0009089IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating leptin level_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0005669IC57BLKSJLeprdbLeprdbLeprdb
• insulin resistance_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005331IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating glucose level_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0005559IC57BLKSJLeprdbLeprdbLeprdb
• abnormal body temperature homeostasis_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001777IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• abnormal glucose homeostasis_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0002078IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating corticosterone level_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0001745IC57BLKSJLeprdbLeprdbLeprdb
• increased total body fat amount_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0010024IC57BLKSJLeprdbLeprdbLeprdb
• impaired glucose tolerance_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005293IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• male infertility_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001925IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating leptin level_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005669IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating insulin level_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0002079IC57BLKSJLeprdbLeprdbLeprdb
• polyphagia_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001433IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• impaired adaptive thermogenesis_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011049IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• small testis_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001147IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased circulating triglyceride level_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001552IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• small seminal vesicle_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001157IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• decreased body length_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0001258IC57BLKSJLeprdbLeprdbLeprdb
• enlarged liver_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0000599IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• absent corpus luteum_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001134IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• increased total body fat amount_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0010024IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• female infertility_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001926IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• neonatal lethality, incomplete penetrance_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0011088IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• decreased body length_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0001258IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln
• impaired glucose tolerance_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0005293IC57BLKSJLeprdbLeprdbLeprdb
• obese_Lepr<db>/Lepr<db>
  http://metadb.riken.jp/0001261IC57BLKSJLeprdbLeprdbLeprdb
• decreased body temperature_Stat3<tm1Flv>/Stat3<tm1Flv>,Tg(Nes-cre)1Kln/0
  http://metadb.riken.jp/0005534IC57BL6SJLStat3tm1FlvStat3tm1FlvTgNescre1Kln0Stat3tm1FlvTgNescre1Kln