Jos. Tournoy, et.al., Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice., Human molecular genetics, 2004, 13

http://rdf.ncbi.nlm.nih.gov/pubmed/15128703

Jos. Tournoy, et.al., Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice., Human molecular genetics, 2004, 13

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• arteritis_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0010138I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• skin inflammation_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0004947I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased incidence of corneal inflammation_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001313I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased anti-single stranded DNA antibody level_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0004771I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• epidermal cyst_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0003414I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• abnormal epidermal layer morphology_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001216I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• hematuria_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0005161I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• abnormal T cell subpopulation ratio_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0003944I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• kidney inflammation_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001859I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased urine protein level_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0002962I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• autoimmune response_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001844I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased leukocyte cell number_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0000218I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased inflammatory response_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001846I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• enlarged lymph nodes_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0000702I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• glomerulonephritis_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0002743I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• spontaneous skin ulceration_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001209I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• skin lesions_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001212I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased immunoglobulin level_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0002461I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• abnormal skin condition_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001191I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• increased susceptibility to autoimmune disorder_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0005350I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• enlarged spleen_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0000691I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• chronic inflammation_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0002499I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• hyperkeratosis_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001242I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• dermatitis_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001194I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• abnormal corneal epithelium morphology_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0006000I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1
• epidermal hyperplasia_Psen1<tm1Bdes>/Psen1<+>,Psen2<tm1Bdes>/Psen2<tm1Bdes>
  http://metadb.riken.jp/0001222I129P2OlaHsdPsen1tm1BdesPsen1Psen2tm1BdesPsen2tm1BdesPsen1tm1BdesPsen2tm1BdesPsen1