Frank. Rosenbauer, et.al., Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1., Nature genetics, 2004, 36

http://rdf.ncbi.nlm.nih.gov/pubmed/15146183

Frank. Rosenbauer, et.al., Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1., Nature genetics, 2004, 36

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Spi1<tm1.1Dgt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045207
• Spi1<tm1Dgt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045206

class

http://purl.org/net/cito/citesAsAuthority

• Spi1<tm1.1Dgt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045207
• Spi1<tm1Dgt>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045206

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal chromosome number_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0004023I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• increased neutrophil cell number_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0000219I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• enlarged spleen_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• increased leukemia incidence_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002026I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• liver hyperplasia_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0005141I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• abnormal proerythroblast morphology_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002416I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• enlarged liver_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0000599I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• abnormal definitive hematopoiesis_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002123I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• premature death_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• abnormal bone marrow morphology_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002397I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• increased leukemia incidence_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002026I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• spleen hyperplasia_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0000693I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• increased tumor incidence_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002020I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• abnormal erythrocyte cell number_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0001586I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• abnormal liver morphology_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0000598I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• abnormal spleen morphology_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0000689I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• abnormal spleen morphology_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0000689I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• increased spleen weight_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0004952I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• increased T cell derived lymphoma incidence_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0002024I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• enlarged spleen_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0000691I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• increased T cell derived lymphoma incidence_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002024I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• decreased B cell number_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0005017I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• increased liver weight_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002981I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• decreased B cell number_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0005017I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• spleen hyperplasia_Spi1<tm1.1Dgt>/Spi1<tm1.1Dgt>
  http://metadb.riken.jp/0000693I129S1Sv129X1SvJSpi1tm11DgtSpi1tm11DgtSpi1tm11Dgt
• premature death_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002083I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt
• abnormal definitive hematopoiesis_Spi1<tm1.3Dgt>/Spi1<tm1.3Dgt>
  http://metadb.riken.jp/0002123I129BALBcC57BL6Spi1tm13DgtSpi1tm13DgtSpi1tm13Dgt