Yasuo. Horie, et.al., Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas., The Journal of clinical investigation, 2004, 113

http://rdf.ncbi.nlm.nih.gov/pubmed/15199412

Yasuo. Horie, et.al., Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas., The Journal of clinical investigation, 2004, 113

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased liver adenoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003324I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• decreased fasted circulating glucose level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0013278I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased metastatic potential_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001272I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• hepatic steatosis_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002628I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased circulating alanine transaminase level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002941I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased liver weight_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002981I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased saturated fatty acid level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005284I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• Mallory bodies_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0014045I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased hepatocellular carcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003331I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• pale liver_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000603I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• oxidative stress_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003674I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased circulating aspartate transaminase level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005343I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased circulating alkaline phosphatase level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002968I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• abnormal hepatocyte morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased hepatocyte number_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0014038I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• abnormal liver sinusoid morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008989I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased insulin sensitivity_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002891I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased hepatocyte proliferation_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• increased liver triglyceride level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0009355I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• decreased circulating insulin level_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002727I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• enlarged liver_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000599I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak
• abnormal cellular cholesterol metabolism_Pten<tm2Mak>/Pten<tm2Mak>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003191I129P2OlaHsdC57BL6C57BL6JDBAPtentm2MakPtentm2MakTgAlbcre21Mgn0TgAlbcre21MgnPtentm2Mak

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating insulin level in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020384
• Mallory bodies in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020380
• decreased fasted circulating glucose level in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020383
• abnormal cellular cholesterol metabolism in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020382
• increased circulating aspartate transaminase level in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020385
• increased hepatocyte number in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020381
• abnormal liver sinusoid morphology in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020379
• increased saturated fatty acid level in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020387
• increased insulin sensitivity in RBRC02301
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1020386