Vesa. Kaartinen, et.al., Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells., Development (Cambridge, England), 2004, 131

http://rdf.ncbi.nlm.nih.gov/pubmed/15226263

Vesa. Kaartinen, et.al., Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells., Development (Cambridge, England), 2004, 131

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cardiac neural crest cell number_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012749I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• conotruncal ridge hypoplasia_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010587I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal third pharyngeal arch artery morphology_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006356I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• enlarged heart_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000274I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal cardiac outflow tract development_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006126I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• impaired cardiac neural crest cell differentiation_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012751I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal pharyngeal arch artery morphology_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002672I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• neonatal lethality, complete penetrance_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011087I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• ventricular septal defect_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010402I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal cardiac neural crest cell migration_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012752I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• lethality throughout fetal growth and development, incomplete penetrance_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011109I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• absent cardiac neural crest cells_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012750I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal aortic arch morphology_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004113I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal sixth pharyngeal arch artery morphology_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006355I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• persistent truncus arteriosis_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• increased heart right ventricle size_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010563I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal aortic arch and aortic arch branch attachment_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010464I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• abnormal brachiocephalic trunk morphology_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010663I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth
• retroesophageal right subclavian artery_Acvr1<tm1Vk>/Acvr1<tm1.1Vk>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004160I129S1Sv129X1SvJC57BL6CBAAcvr1tm1VkAcvr1tm11VkTgWnt1cre11Rth0Acvr1tm11VkAcvr1tm1VkTgWnt1cre11Rth