Sandy. Chang, et.al., Essential role of limiting telomeres in the pathogenesis of Werner syndrome., Nature genetics, 2004, 36

http://rdf.ncbi.nlm.nih.gov/pubmed/15235603

Sandy. Chang, et.al., Essential role of limiting telomeres in the pathogenesis of Werner syndrome., Nature genetics, 2004, 36

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• delayed wound healing_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0002908I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• abnormal femur morphology_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000559I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• decreased trabecular bone mass_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0010873I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• osteoporosis_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000066I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• increased osteosarcoma incidence_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0003789I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• decreased subcutaneous adipose tissue amount_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0008844I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• hyperglycemia_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001559I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• impaired wound healing_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001792I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• small testis_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001147I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• premature death_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0002083I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• increased sarcoma incidence_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0002032I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• alopecia_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000414I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• decreased body weight_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001262I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• cataract_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001304I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• kyphosis_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000160I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• impaired glucose tolerance_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0005293I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• decreased compact bone thickness_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000135I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• abnormal telomere length_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0003155I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• abnormal crypts of Lieberkuhn morphology_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000490I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• abnormal chromosome morphology_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0003702I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• fragile skeleton_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0000061I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• small gonad_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0001116I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• increased circulating insulin level_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0002079I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu
• premature aging_Terc<tm1Rdp>/Terc<tm1Rdp>,Wrn<tm1Lgu>/Wrn<tm1Lgu>
  http://metadb.riken.jp/0003786I129SvBALBcC57BL6SLJTerctm1RdpTerctm1RdpWrntm1LguWrntm1LguTerctm1RdpWrntm1Lgu