Toshiyuki. Araki, et.al., Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation., Nature medicine, 2004, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/15273746

Toshiyuki. Araki, et.al., Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation., Nature medicine, 2004, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Bgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3050284

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000691I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• thin myocardium compact layer_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0004057I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• abnormal heart development_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000267I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• myeloid hyperplasia_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0010373I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• increased leukocyte cell number_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000218I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• atrioventricular septal defect_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0010412I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• double outlet right ventricle_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0000284I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• thin myocardium_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0002652I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• enlarged mitral valve_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0010618I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• decreased body length_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0001258I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• increased cell proliferation_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0000351I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• atrial septal defect_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0010403I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• hemorrhage_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0001914I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• increased neutrophil cell number_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000219I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• abnormal heart development_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0000267I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• perinatal lethality, incomplete penetrance_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0011090I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• ventricular septal defect_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0010402I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• pericardial effusion_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0005312I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• small liver_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0000601I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• embryonic lethality during organogenesis, complete penetrance_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0011098I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• ventricular septal defect_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0010402I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• increased lymphocyte cell number_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0005013I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• decreased body weight_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0001262I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• hepatic necrosis_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0001654I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• hydrops fetalis_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0002192I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• increased cell proliferation_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000351I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• abnormal snout morphology_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000443I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• decreased cardiomyocyte apoptosis_Ptpn11<tm1Bgn>/Ptpn11<tm1Bgn>
  http://metadb.riken.jp/0003223I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11tm1BgnPtpn11tm1Bgn
• small cranium_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0005352I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• decreased cardiomyocyte apoptosis_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0003223I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• hepatic necrosis_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0001654I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11
• double outlet right ventricle_Ptpn11<tm1Bgn>/Ptpn11<+>
  http://metadb.riken.jp/0000284I129S4SvJaeC57BL6JPtpn11tm1BgnPtpn11Ptpn11tm1BgnPtpn11

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1Bgn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3050284