Steffen. Koschmieder, et.al., Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis., Blood, 2005, 105

http://rdf.ncbi.nlm.nih.gov/pubmed/15331442

Steffen. Koschmieder, et.al., Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis., Blood, 2005, 105

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Tal1-tTA)19Dgt
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693328

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Tal1-tTA)19Dgt
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693328

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased bone marrow cell number_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000321IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal small intestine morphology_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000496IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased lymphoma incidence_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0012431IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal myeloblast morphology/development_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002414IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal spleen red pulp morphology_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002356IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased hematopoietic stem cell number_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0004809IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• enlarged liver_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000599IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased sarcoma incidence_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002032IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal splenic cell ratio_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0008826IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal common myeloid progenitor cell morphology_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0006410IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal lymph node morphology_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002339IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased leukocyte cell number_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000218IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal definitive hematopoiesis_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002123IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal lung morphology_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0001175IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased neutrophil cell number_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000219IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• enlarged spleen_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0000691IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• increased megakaryocyte cell number_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0008254IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• premature death_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002083IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt
• abnormal lymphopoiesis_Tg(tetO-BCR/ABL1)2Dgt/0,Tg(Tal1-tTA)19Dgt/0
  http://metadb.riken.jp/0002401IC57BL6DBA2FVBNTgtetOBCRABL12Dgt0TgTal1tTA19Dgt0TgtetOBCRABL12DgtTgTal1tTA19Dgt