Luke T. Krebs, et.al., Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants., Genes & development, 2004, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/15466160

Luke T. Krebs, et.al., Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants., Genes & development, 2004, 18

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Dll4<tm1Grid>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056460

class

http://purl.org/net/cito/citesAsAuthority

• Dll4<tm1Grid>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056460

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal anterior cardinal vein morphology_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0004784I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• abnormal common cardinal vein morphology_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0004786I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• embryonic growth retardation_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0003984EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal vascular regression_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0000364I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• abnormal dorsal aorta morphology_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004787I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• abnormal vitelline vascular remodeling_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0004076I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• embryonic growth retardation_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0003984I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• atretic vasculature_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0000265EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal dorsal aorta morphology_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0004787I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• pericardial effusion_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0005312EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal dorsal aorta morphology_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0004787EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal common cardinal vein morphology_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0004786EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal anterior cardinal vein morphology_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004784I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• pericardial effusion_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0005312I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• abnormal anterior cardinal vein morphology_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0004784EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal vascular development_Efnb2<tm1And>/Efnb2<+>,Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0000259I129S2SvPas129S7SvEvBrdEfnb2tm1AndEfnb2Rbpjtm1KyoRbpjtm1KyoEfnb2Efnb2tm1AndRbpjtm1Kyo
• abnormal vascular regression_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0000364I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• arteriovenous malformation_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0006093EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• absent vitelline blood vessels_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001719I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• decreased spongiotrophoblast size_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0012099I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• arteriovenous malformation_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0006093I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• abnormal capillary morphology_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0003658EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• preweaning lethality, complete penetrance_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0011100EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• arteriovenous malformation_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0006093I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• abnormal placental labyrinth vasculature morphology_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0008803I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• abnormal common cardinal vein morphology_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004786I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• abnormal vascular regression_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0000364EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid
• abnormal blood vessel morphology_Rbpj<tm1Kyo>/Rbpj<tm1Kyo>
  http://metadb.riken.jp/0001614I129S2SvPasC57BL6Rbpjtm1KyoRbpjtm1KyoRbpjtm1Kyo
• embryonic growth retardation_Rbpj<tm1Kyo>/Rbpj<tm1Hon>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003984I129P2OlaHsdC3HC57BL6Rbpjtm1KyoRbpjtm1HonTgTekcre12Flv0TgTekcre12FlvRbpjtm1KyoRbpjtm1Hon
• abnormal vitelline vascular remodeling_Dll4<tm1Grid>/Dll4<+>
  http://metadb.riken.jp/0004076EI129X1SvJBlackSwissorI129X1SvJC57BL6JDll4tm1GridDll4Dll4Dll4tm1Grid

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• arteriovenous malformation in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002009
• abnormal blood vessel morphology in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001998
• abnormal vitelline vascular remodeling in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002003
• abnormal anterior cardinal vein morphology in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002004
• decreased spongiotrophoblast size in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002013
• abnormal vascular regression in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1001997
• embryonic growth retardation in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002002
• abnormal common cardinal vein morphology in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002005
• abnormal dorsal aorta morphology in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002006
• abnormal placental labyrinth vasculature morphology in RBRC01101
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1002011