Xueying. Lin, et.al., Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes., The Journal of clinical investigation, 2004, 114

http://rdf.ncbi.nlm.nih.gov/pubmed/15467829

Xueying. Lin, et.al., Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes., The Journal of clinical investigation, 2004, 114

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Irs2<tm2Mfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3497903

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• hyperglycemia_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001559I129S1Sv129X1SvJC57BL6Irs1tm1JosIrs1Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2cre25MgnIrs2tm2MfwIrs1Irs1tm1Jos
• increased circulating leptin level_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005669I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• insulin resistance_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005331I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• abnormal pancreatic beta cell morphology_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005217I129S1Sv129X1SvJC57BL6Irs1tm1JosIrs1Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2cre25MgnIrs2tm2MfwIrs1Irs1tm1Jos
• abnormal pancreatic beta cell morphology_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005217I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• increased body weight_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0,Tg(Ins2-Irs2)13Mfw/0
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2Irs213Mfw0Irs2tm2MfwTgIns2Irs213MfwTgIns2cre25Mgn
• increased body weight_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• polydipsia_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001426I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• decreased body weight_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001262I129S1Sv129X1SvJC57BL6Irs1tm1JosIrs1Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2cre25MgnIrs2tm2MfwIrs1Irs1tm1Jos
• increased body length_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001257I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• impaired glucose tolerance_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• increased total body fat amount_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• increased circulating glucose level_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• abnormal coat/hair pigmentation_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002075I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• polyphagia_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0001433I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• increased circulating insulin level_Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0Irs2tm2MfwTgIns2cre25Mgn
• decreased circulating insulin level_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0
  http://metadb.riken.jp/0002727I129S1Sv129X1SvJC57BL6Irs1tm1JosIrs1Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2cre25MgnIrs2tm2MfwIrs1Irs1tm1Jos

class

http://purl.org/net/cito/citesAsAuthority

• Irs2<tm2Mfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3497903