Marcus. Conrad, et.al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function., Molecular and cellular biology, 2004, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/15485910

Marcus. Conrad, et.al., Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function., Molecular and cellular biology, 2004, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Txnrd2<tm2.1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512412
• Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512409
• Txnrd2<tm1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512408
• Txnrd2<tm2Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512410

class

http://purl.org/net/cito/citesAsAuthority

• Txnrd2<tm2.1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512412
• Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512409
• Txnrd2<tm1Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512408
• Txnrd2<tm2Marc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3512410

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal liver morphology_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000598I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• dilated heart atrium_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0003140I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• liver vascular congestion_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0010019I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• thin ventricular wall_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000280I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• neonatal lethality, complete penetrance_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0011087I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• congestive heart failure_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0006138I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• abnormal myocardial fiber morphology_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000278I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• embryonic lethality during organogenesis, complete penetrance_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• thin ventricular wall_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000280I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• decreased fetal cardiomyocyte proliferation_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0011395I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• abnormal heart morphology_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000266I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• trabecula carnea hypoplasia_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000295I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• abnormal heart shape_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000277I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• decreased fibroblast proliferation_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0011704I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• abnormal blood flow velocity_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0000233I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• edema_Myl2<tm1(cre)Krc>/Myl2<+>,Txnrd2<tm1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0001785I129P2OlaHsdC57BL6Myl2tm1creKrcMyl2Txnrd2tm1MarcTxnrd2tm11MarcTxnrd2tm1MarcMyl2Txnrd2tm11MarcMyl2tm1creKrc
• thin interventricular septum_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0010725I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• abnormal definitive hematopoiesis_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0002123I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc
• anemia_Txnrd2<tm1.1Marc>/Txnrd2<tm1.1Marc>
  http://metadb.riken.jp/0001577I129P2OlaHsdC57BL6Txnrd2tm11MarcTxnrd2tm11MarcTxnrd2tm11Marc

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD04037
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04037