Dick. Terwel, et.al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice., The Journal of biological chemistry, 2005, 280

http://rdf.ncbi.nlm.nih.gov/pubmed/15509565

Dick. Terwel, et.al., Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice., The Journal of biological chemistry, 2005, 280

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mapt<tm1(MAPT)Vln>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768527
• Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768525

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal motor coordination/ balance_Tg(Thy1-MAPT)1Vln/0
  http://metadb.riken.jp/0001516FVBNTgThy1MAPT1VlnTgThy1MAPT1Vln0TgThy1MAPT1Vln
• limb grasping_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0001513FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• neurofibrillary tangles_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0003214FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• weight loss_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0001263FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• muscular atrophy_Tg(Thy1-MAPT)1Vln/0
  http://metadb.riken.jp/0002269FVBNTgThy1MAPT1VlnTgThy1MAPT1Vln0TgThy1MAPT1Vln
• paralysis_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0000753FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• axon degeneration_Tg(Thy1-MAPT)1Vln/0
  http://metadb.riken.jp/0005405FVBNTgThy1MAPT1VlnTgThy1MAPT1Vln0TgThy1MAPT1Vln
• tau protein deposits_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0004250FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• limb grasping_Tg(Thy1-MAPT)1Vln/0
  http://metadb.riken.jp/0001513FVBNTgThy1MAPT1VlnTgThy1MAPT1Vln0TgThy1MAPT1Vln
• abnormal motor coordination/ balance_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0001516FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• abnormal axon morphology_Tg(Thy1-MAPT)1Vln/0
  http://metadb.riken.jp/0005404FVBNTgThy1MAPT1VlnTgThy1MAPT1Vln0TgThy1MAPT1Vln
• premature death_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0002083FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln
• abnormal motor coordination/ balance_Mapt<tm1(MAPT)Vln>/Mapt<tm1(MAPT)Vln>
  http://metadb.riken.jp/0001516FVBCgMapttm1MAPTVlnMapttm1MAPTVlnMapttm1MAPTVlnMapttm1MAPTVln
• hindlimb paralysis_Tg(Thy1-MAPT*P301L)2Vln/Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/0000755FVBNTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2VlnTgThy1MAPTP301L2Vln

class

http://purl.org/net/cito/citesAsAuthority

• Mapt<tm1(MAPT)Vln>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768527
• Tg(Thy1-MAPT*P301L)2Vln
  http://metadb.riken.jp/db/mgi_rdf/MGI:3768525