Deborah E. Cabin, et.al., Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background., Neurobiology of aging, 2005, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/15585343

Deborah E. Cabin, et.al., Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background., Neurobiology of aging, 2005, 26

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal spinal cord ventral horn morphology_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0005112I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal gait_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001406I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• neuronal intranuclear inclusions_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0004191I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• axon degeneration_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0005405I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal reflex_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001961I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• premature death_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002083I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal spinal nerve morphology_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001077I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• gliosis_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002183I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal male preputial gland morphology_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002717I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• premature death_Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002083I129S6SvEvTacFVBNTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAub
• abnormal posture_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001504I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal ventral spinal root morphology_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0003993I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal motor capabilities/coordination/movement_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0002066I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• kyphosis_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000160I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• short stride length_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001407I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• weight loss_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0001263I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• weakness_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0000746I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• slow postnatal weight gain_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0008489I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm
• abnormal axon morphology_Snca<tm1Nbm>/Snca<tm1Nbm>,Tg(Prnp-SNCA*A53T)AAub/Tg(Prnp-SNCA*A53T)AAub
  http://metadb.riken.jp/0005404I129S6SvEvTacFVBNSncatm1NbmSncatm1NbmTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubTgPrnpSNCAA53TAAubSncatm1Nbm