Natasha L. Harvey, et.al., Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity., Nature genetics, 2005, 37

http://rdf.ncbi.nlm.nih.gov/pubmed/16170315

Natasha L. Harvey, et.al., Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity., Nature genetics, 2005, 37

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Prox1<tm2Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3609548

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal intestine morphology_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0000477I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• increased total body fat amount_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• postnatal lethality, incomplete penetrance_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0011086I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• hepatic steatosis_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0002628I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased fat cell size_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0006094I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• chylothorax_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0003660I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• hypoactivity_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001402I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• respiratory distress_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001954I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased circulating insulin level_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• chylothorax_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003660I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• abnormal suckling behavior_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001436I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased total fat pad weight_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0008908I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• abnormal lymph circulation_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003659I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• increased circulating alanine transaminase level_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0002941I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• edema_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0001785I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• postnatal lethality, incomplete penetrance_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0011086I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased circulating leptin level_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0005669I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased inflammatory response_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001846I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased susceptibility to age related obesity_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0003212I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• increased macrophage cell number_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0005425I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased susceptibility to age related obesity_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0003212I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• abnormal lymph circulation_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0003659I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• abnormal lymphatic vessel morphology_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001879I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• cyanosis_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001575I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• increased liver triglyceride level_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0009355I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• abnormal lymphatic vessel morphology_Prox1<tm2Gco>/Prox1<+>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0001879I129S1SvC57BL6NMRISJLProx1tm2GcoProx1TgTekcre1Ywa0Prox1Prox1tm2GcoTgTekcre1Ywa
• increased circulating glucagon level_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0002712I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• abnormal intestine morphology_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0000477I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco
• edema_Prox1<tm1Gco>/Prox1<+>
  http://metadb.riken.jp/0001785I129S1Sv129X1SvJNMRIProx1tm1GcoProx1Prox1Prox1tm1Gco

class

http://purl.org/net/cito/citesAsAuthority

• Prox1<tm2Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3609548