Christine B F. Thien, et.al., Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion., The EMBO journal, 2005, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/16211006

Christine B F. Thien, et.al., Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion., The EMBO journal, 2005, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cbl<tm2Wlan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3610727

class

http://purl.org/net/cito/citesAsAuthority

• Cbl<tm2Wlan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3610727

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged spleen_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000691I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• thymus hypoplasia_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0001823I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• abnormal T cell activation_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0001828I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal T cell differentiation_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0002145I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• enlarged spleen_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000691I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• abnormal spleen morphology_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000689I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• abnormal thymus size_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0002364I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• increased spleen red pulp amount_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0008476I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• darkened coat color_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0005409I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• thymus hypoplasia_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0001823I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• spleen hyperplasia_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000693I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal foot pigmentation_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0009379I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• spleen hyperplasia_Cbl<tm1Ddlb>/Cbl<tm1Ddlb>
  http://metadb.riken.jp/0000693I129S1SvC57BL6Cbltm1DdlbCbltm1DdlbCbltm1Ddlb
• increased spleen red pulp amount_Cbl<tm1Ddlb>/Cbl<tm1Ddlb>
  http://metadb.riken.jp/0008476I129S1SvC57BL6Cbltm1DdlbCbltm1DdlbCbltm1Ddlb
• abnormal thymus morphology_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000703I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• spleen hyperplasia_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000693I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• increased spleen red pulp amount_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0008476I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• prenatal lethality, incomplete penetrance_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011101I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal lymph node cell ratio_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0008828I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal splenic cell ratio_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0008826I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal T cell physiology_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0002444I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• increased ear pigmentation_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011278I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• lethality throughout fetal growth and development, incomplete penetrance_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011109I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• abnormal foot pigmentation_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0009379I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• neonatal lethality, incomplete penetrance_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011088I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• increased tail pigmentation_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011276I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal thymus morphology_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000703I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• decreased single-positive T cell number_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0008083I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• increased tail pigmentation_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011276I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• darkened coat color_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0005409I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• increased ear pigmentation_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0011278I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• enlarged spleen_Cbl<tm1Ddlb>/Cbl<tm1Ddlb>
  http://metadb.riken.jp/0000691I129S1SvC57BL6Cbltm1DdlbCbltm1DdlbCbltm1Ddlb
• abnormal double-negative T cell morphology_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0002407I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan
• abnormal thymus size_Cbl<tm2Wlan>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0002364I129X1SvJC57BL6Cbltm2WlanCbltm2WlanCbltm2Wlan
• abnormal spleen morphology_Cbl<tm1Ddlb>/Cbl<tm2Wlan>
  http://metadb.riken.jp/0000689I129S1Sv129X1SvJC57BL6Cbltm1DdlbCbltm2WlanCbltm1DdlbCbltm2Wlan