G. Putz, et.al., AML1 deletion in adult mice causes splenomegaly and lymphomas., Oncogene, 2006, 25

http://rdf.ncbi.nlm.nih.gov/pubmed/16247465

G. Putz, et.al., AML1 deletion in adult mice causes splenomegaly and lymphomas., Oncogene, 2006, 25

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm2Buch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798051

class

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm2Buch>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3798051

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hematopoietic stem cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004809I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased mature B cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal thymus lobule morphology_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002367I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased number of Howell-Jolly bodies_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0010178I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• small Peyer's patches_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008135I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal megakaryocyte morphology_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002417I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• thrombocytopenia_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0003179I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased monocyte cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000220I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased CD4-positive, alpha beta T cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008075I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal immune system organ morphology_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002722I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased spleen weight_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004952I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal leukocyte morphology_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008246I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased lymphocyte cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0005016I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased T cell derived lymphoma incidence_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0002024I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal lymph node size_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000701I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased T cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0005018I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased CD8-positive, alpha-beta T cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008079I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• impaired myelopoiesis_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0001602I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased double-positive T cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased spleen white pulp amount_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008479I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased neutrophil cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000219I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased megakaryocyte cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008255I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased lymphoma incidence_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0012431I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• decreased thymus weight_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0004956I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• increased mast cell number_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0000324I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• no abnormal phenotype detected_Runx1<tm2Buch>/Runx1<tm2Buch>
  http://metadb.riken.jp/0002169I129P2OlaHsdC57BL6Runx1tm2BuchRunx1tm2BuchRunx1tm2Buch
• increased spleen red pulp amount_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0008476I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn
• abnormal common myeloid progenitor cell morphology_Runx1<tm2Buch>/Runx1<tm2Buch>,Tg(Mx1-cre)1Cgn/?
  http://metadb.riken.jp/0006410I129P2OlaHsdC57BL6CBARunx1tm2BuchRunx1tm2BuchTgMx1cre1CgnRunx1tm2BuchTgMx1cre1Cgn