Kathryn. Mercer, et.al., Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts., Cancer research, 2005, 65

http://rdf.ncbi.nlm.nih.gov/pubmed/16357158

Kathryn. Mercer, et.al., Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts., Cancer research, 2005, 65

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1Cpri>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612533

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• embryonic lethality between implantation and somite formation, complete penetrance_Braf<tm1Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0011096I129P2OlaHsdBALBcJC57BL6Braftm1CpriBrafTgCMVcre1Cgn0BrafBraftm1CpriTgCMVcre1Cgn
• increased leukemia incidence_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002026I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• enlarged spleen_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• decreased bone marrow cell number_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• abnormal liver morphology_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000598I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• decreased leukocyte cell number_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000221I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• premature death_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• decreased erythrocyte cell number_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf
• increased fibroblast proliferation_Braf<tm1Cpri>/Braf<tm1Cpri>
  http://metadb.riken.jp/0011703I129P2OlaHsdC57BL6Braftm1CpriBraftm1CpriBraftm1Cpri
• extramedullary hematopoiesis_Braf<tm1Cpri>/Braf<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240I129P2OlaHsdC57BL6CBABraftm1CpriBrafTgMx1cre1Cgn0TgMx1cre1CgnBraftm1CpriBraf

class

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1Cpri>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612533