Yoshio. Fujitani, et.al., Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation., Genes & development, 2006, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/16418487

Yoshio. Fujitani, et.al., Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation., Genes & development, 2006, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pdx1<tm3Cvw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3702893

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating glucose level_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0005559I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• decreased circulating insulin level_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0002727I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• postnatal growth retardation_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0001732I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw
• abnormal pancreas development_Pdx1<tm3Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0003934I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1tm3CvwPdx1tm3Cvw
• postnatal lethality, complete penetrance_Pdx1<tm3Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0011085I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1tm3CvwPdx1tm3Cvw
• abnormal pancreas development_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0003934I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw
• abnormal enteroendocrine cell morphology_Pdx1<tm3Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0004141I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1tm3CvwPdx1tm3Cvw
• exocrine pancreatic insufficiency_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0003335I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw
• disorganized pancreatic islets_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009254I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• abnormal stomach pyloric region morphology_Pdx1<tm2Cvw>/Pdx1<tm2Cvw>
  http://metadb.riken.jp/0010785I129S1Sv129X1SvJC57BL6DBAPdx1tm2CvwPdx1tm2CvwPdx1tm2Cvw
• impaired glucose tolerance_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0005293I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• increased pancreatic alpha cell number_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009176I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• abnormal enteroendocrine cell morphology_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0004141I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw
• abnormal intestine morphology_Pdx1<tm2Cvw>/Pdx1<tm2Cvw>
  http://metadb.riken.jp/0000477I129S1Sv129X1SvJC57BL6DBAPdx1tm2CvwPdx1tm2CvwPdx1tm2Cvw
• increased PP cell number_Pdx1<tm3Cvw>/Pdx1<+>
  http://metadb.riken.jp/0009185I129S6SvEvTacC57BL6DBAFVBNPdx1tm3CvwPdx1Pdx1Pdx1tm3Cvw
• impaired glucose tolerance_Pdx1<tm2Cvw>/Pdx1<+>
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6DBAPdx1tm2CvwPdx1Pdx1Pdx1tm2Cvw
• distended stomach_Pdx1<tm2Cvw>/Pdx1<tm2Cvw>
  http://metadb.riken.jp/0009511I129S1Sv129X1SvJC57BL6DBAPdx1tm2CvwPdx1tm2CvwPdx1tm2Cvw
• abnormal stomach enteroendocrine cell morphology_Pdx1<tm2Cvw>/Pdx1<tm2Cvw>
  http://metadb.riken.jp/0010803I129S1Sv129X1SvJC57BL6DBAPdx1tm2CvwPdx1tm2CvwPdx1tm2Cvw
• postnatal lethality, complete penetrance_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0011085I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw
• dehydration_Pdx1<tm2Cvw>/Pdx1<tm3Cvw>
  http://metadb.riken.jp/0001429I129SvC57BL6DBAFVBNPdx1tm2CvwPdx1tm3CvwPdx1tm2CvwPdx1tm3Cvw

class

http://purl.org/net/cito/citesAsAuthority

• Pdx1<tm3Cvw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3702893