Weili. Chen, et.al., A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy., Blood, 2006, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/16551973

Weili. Chen, et.al., A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy., Blood, 2006, 108

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Kmt2a<tm1(AFF1)Ksy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3663920

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hemolymphoid system tumor incidence_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0010296I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• decreased body size_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0001265I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• increased pro-B cell number_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0008186I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal tail position or orientation_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0013176I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased pro-B cell number_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0008186I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• short snout_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000445I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• enlarged spleen_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000691I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased monocyte cell number_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000220I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• big ears_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0000017I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• abnormal facial morphology_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0003743I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased leukemia incidence_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002026I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased B cell derived lymphoma incidence_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0002023I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• increased B cell derived lymphoma incidence_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002023I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal blood cell morphology/development_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0002429I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• lymphoid hyperplasia_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000688I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased malignant tumor incidence_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002018I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased leukemia incidence_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0002026I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• abnormal blood cell morphology/development_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002429I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal facial morphology_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0003743I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• rough coat_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0010179I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal lymphocyte morphology_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002619I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal behavior_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0004924I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• pointed snout_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0000448I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• hunched posture_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0001505I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• decreased body weight_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0001262I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• increased leukocyte cell number_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0000218I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• increased spleen neoplasm incidence_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0005649I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• decreased birth body size_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0009703I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• premature death_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0002083I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• abnormal definitive hematopoiesis_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0002123I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• big ears_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000017I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• myeloid hyperplasia_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0010373I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• decreased body weight_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0001262I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased neutrophil cell number_Kmt2a<tm2(MLLT3)Thr>/Kmt2a<tm2(MLLT3)Thr>
  http://metadb.riken.jp/0000219I129P2OlaHsdC57BL6FVBKmt2atm2MLLT3ThrKmt2atm2MLLT3ThrKmt2atm2MLLT3Thr
• increased neutrophil cell number_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000219I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy
• increased leukocyte cell number_Kmt2a<tm1(AFF1)Ksy>/Kmt2a<+>
  http://metadb.riken.jp/0000218I129S1SvC57BL6FVBKmt2atm1AFF1KsyKmt2aKmt2aKmt2atm1AFF1Ksy

class

http://purl.org/net/cito/citesAsAuthority

• Kmt2a<tm1(AFF1)Ksy>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3663920