Lazaros C. Foukas, et.al., Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation., Nature, 2006, 441

http://rdf.ncbi.nlm.nih.gov/pubmed/16625210

Lazaros C. Foukas, et.al., Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation., Nature, 2006, 441

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pik3ca<tm2Bvan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3770257
• Pik3ca<tm1Bvan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3628805

class

http://purl.org/net/cito/citesAsAuthority

• Pik3ca<tm2Bvan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3770257
• Pik3ca<tm1Bvan>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3628805

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• polyphagia_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0001433I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• increased fat cell size_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0006094I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• insulin resistance_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0005331I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• embryonic growth retardation_Pik3ca<tm1Bvan>/Pik3ca<tm1Bvan>
  http://metadb.riken.jp/0003984I129P2OlaHsdC57BL6Pik3catm1BvanPik3catm1BvanPik3catm1Bvan
• increased circulating insulin level_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0002079I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• decreased skeletal muscle mass_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0004819I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• increased pancreatic beta cell number_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0003645I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• decreased body length_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0001258I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• impaired glucose tolerance_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0005293I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• embryonic lethality during organogenesis, complete penetrance_Pik3ca<tm1Bvan>/Pik3ca<tm1Bvan>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6Pik3catm1BvanPik3catm1BvanPik3catm1Bvan
• postnatal growth retardation_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0001732I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• fetal growth retardation_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0004201I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• decreased lean body mass_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0003961I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• increased circulating leptin level_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0005669I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan
• decreased body weight_Pik3ca<tm1Bvan>/Pik3ca<+>
  http://metadb.riken.jp/0001262I129P2OlaHsdC57BL6Pik3catm1BvanPik3caPik3caPik3catm1Bvan