Sebastian J. Arnold, et.al., Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo., Developmental biology, 2006, 296

http://rdf.ncbi.nlm.nih.gov/pubmed/16765933

Sebastian J. Arnold, et.al., Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo., Developmental biology, 2006, 296

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad9<tm1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3701868
• Smad9<tm2Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514164
• Smad9<tm2.1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3701870

class

http://purl.org/net/cito/citesAsAuthority

• Smad9<tm1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3701868
• Smad9<tm2Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5514164
• Smad9<tm2.1Rob>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3701870

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal craniofacial development_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0003935I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• embryonic lethality during organogenesis, complete penetrance_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0011098I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• abnormal embryonic tissue morphology_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002085I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• absent second pharyngeal arch_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0006345I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal heart development_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0000267I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• failure of heart looping_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0004251I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal direction of heart looping_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0004252I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal extraembryonic tissue morphology_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002086I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• abnormal allantois morphology_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0001726I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• no abnormal phenotype detected_Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002169I129SSvEvSmad9tm21RobSmad9tm21RobSmad9tm21Rob
• abnormal germ cell morphology_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002208I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• embryonic lethality during organogenesis_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0006207I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• abnormal heart development_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0000267I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal blood vessel morphology_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0001614I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• absent primordial germ cells_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0008393I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• embryonic lethality during organogenesis, complete penetrance_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0011098I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• excessive folding of visceral yolk sac_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0011205I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal embryonic growth/weight/body size_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002088I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• prenatal lethality, complete penetrance_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0011091I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad1tm1RobSmad9tm21RobSmad5tm1ZukSmad1Smad5
• abnormal extraembryonic tissue morphology_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002086I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• abnormal embryonic growth/weight/body size_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0002088I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• abnormal rostral-caudal axis patterning_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0005221I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• absent third pharyngeal arch_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0010642I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal nervous system development_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0003861I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• decreased primordial germ cell number_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0008392I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal heart looping_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0000269I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal embryo development_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0001672I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• abnormal left-right axis patterning_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0001706I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal heart development_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0000267I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• no abnormal phenotype detected_Smad9<tm1Rob>/Smad9<tm1Rob>
  http://metadb.riken.jp/0002169I129SSvEvSmad9tm1RobSmad9tm1RobSmad9tm1Rob
• abnormal heart tube morphology_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0000270I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal mesoderm development_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0001680I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal embryo development_Smad5<tm1Zuk>/Smad5<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0001672I129SSvEv129S7SvEvBrdSmad5tm1ZukSmad5Smad9tm21RobSmad9tm21RobSmad5Smad5tm1ZukSmad9tm21Rob
• abnormal nervous system development_Smad1<tm1Rob>/Smad1<+>,Smad9<tm2.1Rob>/Smad9<tm2.1Rob>
  http://metadb.riken.jp/0003861I129SSvEvSmad1tm1RobSmad1Smad9tm21RobSmad9tm21RobSmad9tm21RobSmad1tm1RobSmad1
• abnormal forebrain morphology_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0000783I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal nervous system development_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0003861I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• incomplete rostral neuropore closure_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0000928I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob
• abnormal somite development_Smad1<tm1Rob>/Smad1<+>,Smad5<tm1Zuk>/Smad5<+>
  http://metadb.riken.jp/0001688I129SSvEv129S7SvEvBrdSmad1tm1RobSmad1Smad5tm1ZukSmad5Smad1Smad5Smad5tm1ZukSmad1tm1Rob