Jean M. Jasinski, et.al., Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout., Diabetes, 2006, 55

http://rdf.ncbi.nlm.nih.gov/pubmed/16804066

Jean M. Jasinski, et.al., Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout., Diabetes, 2006, 55

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(TcrbBDC12-4.1)82Gse
  http://metadb.riken.jp/db/mgi_rdf/MGI:3687034
• Tg(TcraBDC12-4.1)10Jos
  http://metadb.riken.jp/db/mgi_rdf/MGI:3687036

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased susceptibility to autoimmune diabetes_H2<q>/H2<q>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004804I129S7SvEvBrdC57BL6FVBNODH2qH2qRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0Rag1tm1MomH2qTgTcrbBDC124182GseTgTcraBDC124110Jos
• increased susceptibility to autoimmune diabetes_H2<g7>/H2<q>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004803I129S7SvEvBrdC57BL6FVBNODH2g7H2qRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcrbBDC124182GseH2qRag1tm1MomTgTcraBDC124110JosH2g7
• decreased lymphocyte cell number_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0005016I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomRag1tm1Mom
• increased susceptibility to autoimmune diabetes_H2<g7>/H2<g7>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004803I129S7SvEvBrdC57BL6FVBNODH2g7H2g7Rag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcrbBDC124182GseRag1tm1MomTgTcraBDC124110JosH2g7
• increased circulating glucose level_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0005559I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• decreased lymphocyte cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0005016I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• small thymus_Rag1<tm1Mom>/Rag1<tm1Mom>
  http://metadb.riken.jp/0000706I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomRag1tm1Mom
• insulitis_H2<g7>/H2<g7>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004031I129S7SvEvBrdC57BL6FVBNODH2g7H2g7TgTcraBDC124110Jos0TgTcrbBDC124182Gse0H2g7TgTcraBDC124110JosTgTcrbBDC124182Gse
• decreased susceptibility to autoimmune diabetes_H2<g7>/H2<g7>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004804I129S7SvEvBrdC57BL6FVBNODH2g7H2g7TgTcraBDC124110Jos0TgTcrbBDC124182Gse0H2g7TgTcraBDC124110JosTgTcrbBDC124182Gse
• increased susceptibility to autoimmune diabetes_H2<g7>/H2<g7>,Ins2<tm1Jja>/Ins2<tm1Jja>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004803I129S2SvPas129S7SvEvBrdC57BL6FVBNODH2g7H2g7Ins2tm1JjaIns2tm1JjaRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0Ins2tm1JjaTgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1MomH2g7
• decreased pancreatic beta cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0003339I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• increased circulating glucose level_H2<g7>/H2<g7>,Ins2<tm1Jja>/Ins2<tm1Jja>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0005559I129S2SvPas129S7SvEvBrdC57BL6FVBNODH2g7H2g7Ins2tm1JjaIns2tm1JjaRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0Ins2tm1JjaTgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1MomH2g7
• decreased thymus weight_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004956I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• insulitis_H2<g7>/H2<g7>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004031I129S7SvEvBrdC57BL6FVBNODH2g7H2g7Rag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcrbBDC124182GseRag1tm1MomTgTcraBDC124110JosH2g7
• decreased CD4-positive, alpha beta T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0008075I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• increased susceptibility to autoimmune diabetes_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0004803I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom
• increased double-positive T cell number_Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(TcraBDC12-4.1)10Jos/0,Tg(TcrbBDC12-4.1)82Gse/0
  http://metadb.riken.jp/0005091I129S7SvEvBrdC57BL6FVBNODRag1tm1MomRag1tm1MomTgTcraBDC124110Jos0TgTcrbBDC124182Gse0TgTcraBDC124110JosTgTcrbBDC124182GseRag1tm1Mom

class

http://purl.org/net/cito/citesAsAuthority

• Tg(TcrbBDC12-4.1)82Gse
  http://metadb.riken.jp/db/mgi_rdf/MGI:3687034
• Tg(TcraBDC12-4.1)10Jos
  http://metadb.riken.jp/db/mgi_rdf/MGI:3687036