Masahiro. Yamamoto, et.al., Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling., Nature immunology, 2006, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/16862162

Masahiro. Yamamoto, et.al., Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling., Nature immunology, 2006, 7

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ube2n<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655236
• Ube2n<tm2Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655238

class

http://purl.org/net/cito/citesAsAuthority

• Ube2n<tm1Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655236
• Ube2n<tm2Aki>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655238

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal macrophage physiology_Ube2n<tm1Aki>/Ube2n<tm1Aki>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002451I129P2OlaHsdC57BL6Ube2ntm1AkiUbe2ntm1AkiLyz2tm1creIfoLyz2Ube2ntm1AkiLyz2Lyz2tm1creIfo
• abnormal spleen marginal zone morphology_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0002362I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• embryonic lethality during organogenesis, complete penetrance_Ube2n<tm2Aki>/Ube2n<tm2Aki>
  http://metadb.riken.jp/0011098I129P2OlaHsdC57BL6Ube2ntm2AkiUbe2ntm2AkiUbe2ntm2Aki
• decreased immunoglobulin level_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0002460I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• abnormal B cell physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0002459I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• decreased B cell proliferation_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0005093I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• decreased B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0005017I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• no abnormal phenotype detected_Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0002169I129P2OlaHsdC57BL6Ube2ntm1AkiUbe2ntm1AkiUbe2ntm1Aki
• increased B cell apoptosis_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0008782I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• abnormal humoral immune response_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0001800I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki
• decreased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ube2n<tm1Aki>/Ube2n<tm1Aki>
  http://metadb.riken.jp/0008182I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ube2ntm1AkiUbe2ntm1AkiCd19Cd19tm1creCgnUbe2ntm1Aki