Maria D. Lalioti, et.al., Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule., Nature genetics, 2006, 38

http://rdf.ncbi.nlm.nih.gov/pubmed/16964266

Maria D. Lalioti, et.al., Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule., Nature genetics, 2006, 38

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Wnk4)#Rpl
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525134
• Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525135

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased systemic arterial systolic blood pressure_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0006264IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• decreased circulating chloride level_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0003020IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• abnormal distal convoluted tubule morphology_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0004757IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• abnormal kidney physiology_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0002136IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• increased systemic arterial systolic blood pressure_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0006144IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• decreased circulating potassium level_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0005628IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• decreased circulating magnesium level_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0010093IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• decreased systemic arterial diastolic blood pressure_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0006263IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• increased urine calcium level_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0005441IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• abnormal distal convoluted tubule morphology_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0004757IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• decreased urine calcium level_Tg(Wnk4)#Rpl/Tg(Wnk4)#Rpl
  http://metadb.riken.jp/0002986IC3HC57BL6TgWnk4RplTgWnk4RplTgWnk4Rpl
• increased circulating chloride level_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0003019IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• decreased circulating bicarbonate level_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0003017IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• increased circulating magnesium level_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0010092IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• hyperkalemia_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0012339IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• premature death_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0002083IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl
• increased systemic arterial diastolic blood pressure_Tg(Wnk4*Q562E)#Rpl/Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/0006143IC3HC57BL6TgWnk4Q562ERplTgWnk4Q562ERplTgWnk4Q562ERpl

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Wnk4)#Rpl
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525134
• Tg(Wnk4*Q562E)#Rpl
  http://metadb.riken.jp/db/mgi_rdf/MGI:5525135