Zhigang. Yu, et.al., Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model., The Journal of clinical investigation, 2006, 116

http://rdf.ncbi.nlm.nih.gov/pubmed/16981011

Zhigang. Yu, et.al., Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model., The Journal of clinical investigation, 2006, 116

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• distended urinary bladder_Ar<tm4(AR)Dmr>/Y
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• muscle weakness_Ar<tm4(AR)Dmr>/Ar<+>
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• muscle weakness_Ar<tm4(AR)Dmr>/Y
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• progressive muscle weakness_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0000748I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• myopathy_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0000751I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• motor neuron degeneration_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0000938I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
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• abnormal spinal cord morphology_Ar<tm4(AR)Dmr>/Y
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• decreased body weight_Ar<tm4(AR)Dmr>/Y
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• decreased body size_Ar<tm4(AR)Dmr>/Y
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• reduced male fertility_Ar<tm4(AR)Dmr>/Y
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• premature death_Ar<tm4(AR)Dmr>/Y
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• abnormal seminiferous tubule morphology_Ar<tm4(AR)Dmr>/Y
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• decreased circulating testosterone level_Ar<tm4(AR)Dmr>/Y
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• increased circulating testosterone level_Ar<tm4(AR)Dmr>/Ar<+>
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• abnormal skeletal muscle fiber morphology_Ar<tm4(AR)Dmr>/Y
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• impaired muscle relaxation_Ar<tm4(AR)Dmr>/Y
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• testicular atrophy_Ar<tm4(AR)Dmr>/Y
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• abnormal muscle electrophysiology_Ar<tm4(AR)Dmr>/Y
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• increased circulating creatinine level_Ar<tm4(AR)Dmr>/Y
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• increased blood urea nitrogen level_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0005565I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• increased circulating potassium level_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0005627I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• increased variability of skeletal muscle fiber size_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0009403I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• centrally nucleated skeletal muscle fibers_Ar<tm4(AR)Dmr>/Y
  http://metadb.riken.jp/0009404I129S1SvC57BL6JArtm4ARDmrYArtm4ARDmr
• skeletal muscle fiber atrophy_Ar<tm4(AR)Dmr>/Y
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• abnormal blood homeostasis_Ar<tm4(AR)Dmr>/Y
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• decreased grip strength_Ar<tm4(AR)Dmr>/Ar<+>
  http://metadb.riken.jp/0010053I129S1SvC57BL6JArtm4ARDmrArArtm4ARDmrAr
• decreased grip strength_Ar<tm4(AR)Dmr>/Y
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• increased urine major urinary protein level_Ar<tm4(AR)Dmr>/Ar<+>
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