John A. D'Orazio, et.al., Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning., Nature, 2006, 443

http://rdf.ncbi.nlm.nih.gov/pubmed/16988713

John A. D'Orazio, et.al., Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning., Nature, 2006, 443

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• skin lesions_Mc1r<e>/Mc1r<e>,Xpc<tm1Brd>/Xpc<tm1Brd>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0001212I129S7SvEvBrdC57BL6SJLMc1reMc1reXpctm1BrdXpctm1BrdTgKRT14Kitl1Takk0Mc1reXpctm1BrdTgKRT14Kitl1Takk
• thick epidermis_Mc1r<e>/Mc1r<e>,Xpc<tm1Brd>/Xpc<tm1Brd>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0001219I129S7SvEvBrdC57BL6SJLMc1reMc1reXpctm1BrdXpctm1BrdTgKRT14Kitl1Takk0Mc1reXpctm1BrdTgKRT14Kitl1Takk
• abnormal keratinocyte apoptosis_Tyr<c-2J>/Tyr<c-2J>
  http://metadb.riken.jp/0001224B6CgTyrc2JJTyrc2JTyrc2JTyrc2J
• abnormal keratinocyte apoptosis_Mc1r<e>/Mc1r<e>
  http://metadb.riken.jp/0001224C57BL6JMc1reJMc1reMc1reMc1re
• weight loss_Mc1r<e>/Mc1r<e>,Xpc<tm1Brd>/Xpc<tm1Brd>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0001263I129S7SvEvBrdC57BL6SJLMc1reMc1reXpctm1BrdXpctm1BrdTgKRT14Kitl1Takk0Mc1reXpctm1BrdTgKRT14Kitl1Takk
• increased tumor incidence_Mc1r<e>/Mc1r<e>,Xpc<tm1Brd>/Xpc<tm1Brd>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0002020I129S7SvEvBrdC57BL6SJLMc1reMc1reXpctm1BrdXpctm1BrdTgKRT14Kitl1Takk0Mc1reXpctm1BrdTgKRT14Kitl1Takk
他6件を見る
• abnormal skin pigmentation_Mc1r<e>/Mc1r<e>
  http://metadb.riken.jp/0002095C57BL6JMc1reJMc1reMc1reMc1re
• increased squamous cell carcinoma incidence_Mc1r<e>/Mc1r<e>,Xpc<tm1Brd>/Xpc<tm1Brd>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0004207I129S7SvEvBrdC57BL6SJLMc1reMc1reXpctm1BrdXpctm1BrdTgKRT14Kitl1Takk0Mc1reXpctm1BrdTgKRT14Kitl1Takk
• increased cellular sensitivity to ionizing radiation_Tyr<c-2J>/Tyr<c-2J>
  http://metadb.riken.jp/0004227B6CgTyrc2JJTyrc2JTyrc2JTyrc2J
• increased cellular sensitivity to ionizing radiation_Mc1r<e>/Mc1r<e>
  http://metadb.riken.jp/0004227C57BL6JMc1reJMc1reMc1reMc1re
• abnormal melanogenesis_Mc1r<e>/Mc1r<e>
  http://metadb.riken.jp/0005077C57BL6JMc1reJMc1reMc1reMc1re
• abnormal melanogenesis_Mc1r<e>/Mc1r<e>,Tg(KRT14-Kitl)1Takk/0
  http://metadb.riken.jp/0005077IC57BL6SJLMc1reMc1reTgKRT14Kitl1Takk0TgKRT14Kitl1TakkMc1re

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal keratinocyte apoptosis in RBRC04862
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007017
• abnormal skin pigmentation in RBRC04862
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007020
• increased cellular sensitivity to ionizing radiation in RBRC04862
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007021
• abnormal melanogenesis in RBRC04862
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1007024
• abnormal keratinocyte apoptosis in RBRC05738
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1008616
• increased cellular sensitivity to ionizing radiation in RBRC05738
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1008621
他2件を見る
• abnormal keratinocyte apoptosis in RBRC05798
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014043
• increased cellular sensitivity to ionizing radiation in RBRC05798
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1014055