Min. Xie, et.al., A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103

http://rdf.ncbi.nlm.nih.gov/pubmed/17085580

Min. Xie, et.al., A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Map3k7<tm1.1Mds>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3696053
• Tg(CAG-Map3k7*K63W)1232Mds
  http://metadb.riken.jp/db/mgi_rdf/MGI:4461396
• Map3k7<tm1Mds>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3696052

class

http://purl.org/net/cito/citesAsAuthority

• Map3k7<tm1.1Mds>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3696053
• Tg(CAG-Map3k7*K63W)1232Mds
  http://metadb.riken.jp/db/mgi_rdf/MGI:4461396
• Map3k7<tm1Mds>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3696052

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cardiac muscle glycogen level_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0014071IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• hypoactivity_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001402IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• embryonic lethality during organogenesis, complete penetrance_Map3k7<tm1.1Mds>/Map3k7<tm1.1Mds>
  http://metadb.riken.jp/0011098NSMap3k7tm11MdsMap3k7tm11MdsMap3k7tm11Mds
• abnormal blood vessel morphology_Map3k7<tm1.1Mds>/Map3k7<tm1.1Mds>
  http://metadb.riken.jp/0001614NSMap3k7tm11MdsMap3k7tm11MdsMap3k7tm11Mds
• abnormal QRS complex_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003898IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• postnatal growth retardation_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001732IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• embryonic lethality during organogenesis, complete penetrance_Map3k7<tm1Mds>/Map3k7<tm1Mds>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011098IFVBNMap3k7tm1MdsMap3k7tm1MdsTgMyh6cre2182Mds0Map3k7tm1MdsTgMyh6cre2182Mds
• abnormal myocardial fiber morphology_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000278IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• abnormal heart morphology_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000266IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• abnormal vitelline vasculature morphology_Map3k7<tm1.1Mds>/Map3k7<tm1.1Mds>
  http://metadb.riken.jp/0003229NSMap3k7tm11MdsMap3k7tm11MdsMap3k7tm11Mds
• cardiac hypertrophy_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001625IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• periorbital edema_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001788IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• abnormal atrial thrombosis_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001855IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• prolonged QRS complex duration_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010392IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• abnormal cardiovascular system physiology_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0001544IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• thin ventricular wall_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0000280IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• dilated heart ventricle_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0008022IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• cardiomyopathy_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005330IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• abnormal ventricle papillary muscle morphology_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004058IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• postnatal lethality, complete penetrance_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011085IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds
• shortened PR interval_Tg(CAG-Map3k7*K63W)1232Mds/0,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010511IFVBNTgCAGMap3k7K63W1232Mds0TgMyh6cre2182Mds0TgCAGMap3k7K63W1232MdsTgMyh6cre2182Mds