Palle G. Laustsen, et.al., Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function., Molecular and cellular biology, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17189427

Palle G. Laustsen, et.al., Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function., Molecular and cellular biology, 2007, 27

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased heart weight_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002834I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• small myocardial fiber_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0004565I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• abnormal breathing pattern_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001951I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• decreased heart rate_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0005333I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• postnatal growth retardation_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001732I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• cardiac interstitial fibrosis_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0005608I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• decreased body weight_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001262I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• postnatal lethality, complete penetrance_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0011085I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• thin ventricular wall_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0000280I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• decreased ventricle muscle contractility_Igf1r<tm1.1Mhz>/Igf1r<+>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0005598I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzIgf1rInsrtm1KhnTgCkmmcre5Khn
• abnormal myocardial fiber morphology_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0000278I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• premature death_Igf1r<tm1.1Mhz>/Igf1r<+>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002083I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzIgf1rInsrtm1KhnTgCkmmcre5Khn
• congestive heart failure_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0006138I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• small heart_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002188I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• hypoactivity_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001402I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• dilated cardiomyopathy_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002795I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• increased heart weight_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0002833I129SvC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5Khn
• abnormal breathing pattern_Igf1r<tm1.1Mhz>/Igf1r<+>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001951I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzIgf1rInsrtm1KhnTgCkmmcre5Khn
• thin interventricular septum_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0010725I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• decreased ventricle muscle contractility_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0005598I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn
• hypoactivity_Igf1r<tm1.1Mhz>/Igf1r<+>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0001402I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzIgf1rInsrtm1KhnTgCkmmcre5Khn
• abnormal heart left ventricle morphology_Igf1r<tm1.1Mhz>/Igf1r<tm1.1Mhz>,Insr<tm1Khn>/Insr<tm1Khn>,Tg(Ckmm-cre)5Khn/0
  http://metadb.riken.jp/0003921I129Sv129S4SvJaeC57BL6FVBIgf1rtm11MhzIgf1rtm11MhzInsrtm1KhnInsrtm1KhnTgCkmmcre5Khn0Igf1rtm11MhzTgCkmmcre5KhnInsrtm1Khn