Vincent. Sauzeau, et.al., Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice., Molecular biology of the cell, 2007, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/17202406

Vincent. Sauzeau, et.al., Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice., Molecular biology of the cell, 2007, 18

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• cardiac fibrosis_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0003141I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased circulating adrenaline level_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005662NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• enlarged adrenal medulla_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008300I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased heart rate_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0002626NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• increased circulating aldosterone level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0002666I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased urine sodium level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0006317I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• enlarged myocardial fiber_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0004564I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased mean systemic arterial blood pressure_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0004875I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• hydroencephaly_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0001891I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased dopamine level_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0001906NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• abnormal physiological response to xenobiotic_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008872I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased heart rate_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0002626I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• abnormal adrenal gland secretion_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0001739I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• adrenal medulla hyperplasia_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0008301I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased circulating noradrenaline level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005665I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased angiotensin I-converting enzyme activity_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0003184NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• abnormal heart morphology_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0000266I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased mean systemic arterial blood pressure_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0004875NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• increased circulating noradrenaline level_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005665NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• increased dopamine level_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0001906I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• increased circulating noradrenaline level_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005665I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• abnormal aorta tunica media morphology_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0009873I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• heart left ventricle hypertrophy_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0002625I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased heart rate_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0002626I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• oliguria_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0003620I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased renin activity_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005582I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased angiotensin I-converting enzyme activity_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0003184I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• renal fibrosis_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0003985I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased circulating antidiuretic hormone level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005610I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• decreased creatinine clearance_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005558I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• hypertension_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0000231I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased renin activity_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005582I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• increased mean systemic arterial blood pressure_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0004875I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• increased renin activity_Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005582NSVav3tm1XrbVav3tm1XrbVav3tm1Xrb
• vascular smooth muscle hyperplasia_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005489I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• abnormal bradykinin level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0009812I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased circulating renin level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0003352I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr
• increased circulating adrenaline level_Vav2<tm1Tnr>/Vav2<tm1Tnr>,Vav3<tm1Xrb>/Vav3<tm1Xrb>
  http://metadb.riken.jp/0005662I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav3tm1XrbVav3tm1XrbVav3tm1XrbVav2tm1Tnr
• increased circulating adrenaline level_Vav2<tm1Tnr>/Vav2<tm1Tnr>
  http://metadb.riken.jp/0005662I129P2OlaHsdVav2tm1TnrVav2tm1TnrVav2tm1Tnr