Christina J. Matheny, et.al., Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles., The EMBO journal, 2007, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/17290219

Christina J. Matheny, et.al., Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles., The EMBO journal, 2007, 26

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm4Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707165
• Runx1<tm5Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707170
• Runx1<tm7Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707172
• Runx1<tm6Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707171
• Runx1<tm8Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707173

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal embryonic hematopoiesis_Runx1<tm5Spe>/Runx1<tm5Spe>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm5SpeRunx1tm5SpeRunx1tm5Spe
• abnormal embryonic hematopoiesis_Runx1<tm8Spe>/Runx1<+>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm8SpeRunx1Runx1tm8SpeRunx1
• intraventricular hemorrhage_Runx1<tm6Spe>/Runx1<tm6Spe>
  http://metadb.riken.jp/0001917I129SvC57BL6Runx1tm6SpeRunx1tm6SpeRunx1tm6Spe
• hemoperitoneum_Runx1<tm7Spe>/Runx1<tm7Spe>
  http://metadb.riken.jp/0005435I129SvC57BL6Runx1tm7SpeRunx1tm7SpeRunx1tm7Spe
• embryonic lethality during organogenesis, complete penetrance_Runx1<tm5Spe>/Runx1<tm5Spe>
  http://metadb.riken.jp/0011098I129SvC57BL6Runx1tm5SpeRunx1tm5SpeRunx1tm5Spe
• abnormal embryonic hematopoiesis_Runx1<tm6Spe>/Runx1<tm6Spe>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm6SpeRunx1tm6SpeRunx1tm6Spe
• hemopericardium_Runx1<tm7Spe>/Runx1<tm7Spe>
  http://metadb.riken.jp/0005244I129SvC57BL6Runx1tm7SpeRunx1tm7SpeRunx1tm7Spe
• abnormal embryonic hematopoiesis_Runx1<tm5Spe>/Runx1<+>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm5SpeRunx1Runx1tm5SpeRunx1
• postnatal growth retardation_Runx1<tm8Spe>/Runx1<tm8Spe>
  http://metadb.riken.jp/0001732I129SvC57BL6Runx1tm8SpeRunx1tm8SpeRunx1tm8Spe
• increased monocyte cell number_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0000220I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• hemoperitoneum_Runx1<tm6Spe>/Runx1<tm6Spe>
  http://metadb.riken.jp/0005435I129SvC57BL6Runx1tm6SpeRunx1tm6SpeRunx1tm6Spe
• hemopericardium_Runx1<tm5Spe>/Runx1<tm5Spe>
  http://metadb.riken.jp/0005244I129SvC57BL6Runx1tm5SpeRunx1tm5SpeRunx1tm5Spe
• decreased leukocyte cell number_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0000221I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• decreased lymphocyte cell number_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0005016I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• abnormal embryonic hematopoiesis_Runx1<tm4Spe>/Runx1<+>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm4SpeRunx1Runx1tm4SpeRunx1
• decreased CD4-positive, alpha beta T cell number_Runx1<tm5Spe>/Runx1<+>
  http://metadb.riken.jp/0008075I129SvC57BL6Runx1tm5SpeRunx1Runx1tm5SpeRunx1
• hemopericardium_Runx1<tm6Spe>/Runx1<tm6Spe>
  http://metadb.riken.jp/0005244I129SvC57BL6Runx1tm6SpeRunx1tm6SpeRunx1tm6Spe
• decreased CD4-positive, alpha beta T cell number_Runx1<tm6Spe>/Runx1<+>
  http://metadb.riken.jp/0008075I129SvC57BL6Runx1tm6SpeRunx1Runx1tm6SpeRunx1
• abnormal embryonic hematopoiesis_Runx1<tm1Spe>/Runx1<+>
  http://metadb.riken.jp/0003396EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Runx1tm1SpeRunx1Runx1tm1SpeRunx1
• intraventricular hemorrhage_Runx1<tm5Spe>/Runx1<tm5Spe>
  http://metadb.riken.jp/0001917I129SvC57BL6Runx1tm5SpeRunx1tm5SpeRunx1tm5Spe
• decreased CD4-positive, alpha beta T cell number_Runx1<tm7Spe>/Runx1<+>
  http://metadb.riken.jp/0008075I129SvC57BL6Runx1tm7SpeRunx1Runx1tm7SpeRunx1
• abnormal embryonic hematopoiesis_Runx1<tm7Spe>/Runx1<tm7Spe>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm7SpeRunx1tm7SpeRunx1tm7Spe
• thrombocytopenia_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0003179I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• abnormal embryonic hematopoiesis_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• postnatal lethality, complete penetrance_Runx1<tm8Spe>/Runx1<tm8Spe>
  http://metadb.riken.jp/0011085I129SvC57BL6Runx1tm8SpeRunx1tm8SpeRunx1tm8Spe
• lung inflammation_Runx1<tm8Spe>/Runx1<tm8Spe>
  http://metadb.riken.jp/0001861I129SvC57BL6Runx1tm8SpeRunx1tm8SpeRunx1tm8Spe
• hemoperitoneum_Runx1<tm5Spe>/Runx1<tm5Spe>
  http://metadb.riken.jp/0005435I129SvC57BL6Runx1tm5SpeRunx1tm5SpeRunx1tm5Spe
• intraventricular hemorrhage_Runx1<tm7Spe>/Runx1<tm7Spe>
  http://metadb.riken.jp/0001917I129SvC57BL6Runx1tm7SpeRunx1tm7SpeRunx1tm7Spe
• postnatal growth retardation_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0001732I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• abnormal embryonic hematopoiesis_Runx1<tm6Spe>/Runx1<+>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm6SpeRunx1Runx1tm6SpeRunx1
• embryonic lethality during organogenesis, complete penetrance_Runx1<tm6Spe>/Runx1<tm6Spe>
  http://metadb.riken.jp/0011098I129SvC57BL6Runx1tm6SpeRunx1tm6SpeRunx1tm6Spe
• decreased CD4-positive, alpha beta T cell number_Runx1<tm4Spe>/Runx1<+>
  http://metadb.riken.jp/0008075I129SvC57BL6Runx1tm4SpeRunx1Runx1tm4SpeRunx1
• decreased CD4-positive, alpha beta T cell number_Runx1<tm8Spe>/Runx1<+>
  http://metadb.riken.jp/0008075I129SvC57BL6Runx1tm8SpeRunx1Runx1tm8SpeRunx1
• postnatal lethality, incomplete penetrance_Runx1<tm4Spe>/Runx1<tm4Spe>
  http://metadb.riken.jp/0011086I129SvC57BL6Runx1tm4SpeRunx1tm4SpeRunx1tm4Spe
• abnormal embryonic hematopoiesis_Runx1<tm8Spe>/Runx1<tm8Spe>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm8SpeRunx1tm8SpeRunx1tm8Spe
• abnormal embryonic hematopoiesis_Runx1<tm7Spe>/Runx1<+>
  http://metadb.riken.jp/0003396I129SvC57BL6Runx1tm7SpeRunx1Runx1tm7SpeRunx1
• decreased CD4-positive, alpha beta T cell number_Runx1<tm1Spe>/Runx1<+>
  http://metadb.riken.jp/0008075EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Runx1tm1SpeRunx1Runx1tm1SpeRunx1
• embryonic lethality during organogenesis, complete penetrance_Runx1<tm7Spe>/Runx1<tm7Spe>
  http://metadb.riken.jp/0011098I129SvC57BL6Runx1tm7SpeRunx1tm7SpeRunx1tm7Spe

class

http://purl.org/net/cito/citesAsAuthority

• Runx1<tm4Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707165
• Runx1<tm5Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707170
• Runx1<tm7Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707172
• Runx1<tm6Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707171
• Runx1<tm8Spe>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3707173