Nadja. Herbach, et.al., Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice., Diabetes, 2007, 56

http://rdf.ncbi.nlm.nih.gov/pubmed/17303807

Nadja. Herbach, et.al., Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice., Diabetes, 2007, 56

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ins2<C95S>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3713760

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• insulin resistance_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0005331C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• decreased pancreatic beta cell number_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0003339C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• decreased circulating insulin level_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0002727C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased circulating glucose level_Ins2<C95S>/Ins2<C95S>
  http://metadb.riken.jp/0005559C3HeBFeJIns2C95SIns2C95SIns2C95SIns2C95S
• premature death_Ins2<C95S>/Ins2<C95S>
  http://metadb.riken.jp/0002083C3HeBFeJIns2C95SIns2C95SIns2C95SIns2C95S
• abnormal pancreatic islet morphology_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0005215C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• decreased body weight_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0001262C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased pancreatic alpha cell number_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0009176C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased urine glucose level_Ins2<C95S>/Ins2<C95S>
  http://metadb.riken.jp/0001759C3HeBFeJIns2C95SIns2C95SIns2C95SIns2C95S
• hyperglycemia_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0001559C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased susceptibility to autoimmune diabetes_Ins2<C95S>/Ins2<C95S>
  http://metadb.riken.jp/0004803C3HeBFeJIns2C95SIns2C95SIns2C95SIns2C95S
• abnormal pancreatic beta cell physiology_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0003562C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• decreased insulin secretion_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0003059C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• abnormal pancreatic beta cell morphology_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0005217C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• decreased body weight_Ins2<C95S>/Ins2<C95S>
  http://metadb.riken.jp/0001262C3HeBFeJIns2C95SIns2C95SIns2C95SIns2C95S
• increased urine glucose level_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0001759C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased circulating glucose level_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0005559C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• increased susceptibility to autoimmune diabetes_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0004803C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S
• disorganized pancreatic islets_Ins2<C95S>/Ins2<+>
  http://metadb.riken.jp/0009254C3HeBFeJIns2C95SIns2C95SIns2Ins2Ins2C95S

class

http://purl.org/net/cito/citesAsAuthority

• Ins2<C95S>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3713760