Matthew M. Goddeeris, et.al., Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development., Development (Cambridge, England), 2007, 134

http://rdf.ncbi.nlm.nih.gov/pubmed/17344228

Matthew M. Goddeeris, et.al., Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development., Development (Cambridge, England), 2007, 134

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smo<tm2.1Amc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834775

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• transposition of great arteries_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004110I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• impaired cardiac neural crest cell differentiation_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0012751I129S4SvJaeSor129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0GtROSA26Sortm1SorGtROSA26SorGtROSA26SorTgWnt1cre11RthGtROSA26Sortm1SorSmotm2AmcSmotm21Amc
• increased cardiac neural crest cell number_Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0012748I129X1SvJC57BL6JCBAJGtROSA26Sortm1SmoEYFPAmcGtROSA26SorTgWnt1cre11Rth0GtROSA26Sortm1SmoEYFPAmcTgWnt1cre11RthGtROSA26Sor
• abnormal cardiac outflow tract development_Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006126I129X1SvJC57BL6JCBAJGtROSA26Sortm1SmoEYFPAmcGtROSA26SorTgWnt1cre11Rth0GtROSA26Sortm1SmoEYFPAmcTgWnt1cre11RthGtROSA26Sor
• abnormal cardiac outflow tract development_Smo<tm2Amc>/Smo<tm2.1Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0006126I129S7SvEvBrd129X1SvJSmotm2AmcSmotm21AmcNkx25tm1creRjsNkx25Nkx25Nkx25tm1creRjsSmotm21AmcSmotm2Amc
• pulmonary artery hypoplasia_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0010460I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• decreased cardiac neural crest cell number_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0,Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0012749I129S4SvJaeSor129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0GtROSA26Sortm1SorGtROSA26SorGtROSA26SorTgWnt1cre11RthGtROSA26Sortm1SorSmotm2AmcSmotm21Amc
• abnormal artery morphology_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002191I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• abnormal neural crest cell apoptosis_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0009844I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• persistent truncus arteriosis_Shh<tm1Chg>/Shh<tm2Chg>,Tg(Mef2c-cre)2Blk/0
  http://metadb.riken.jp/0002633I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2ChgTgMef2ccre2Blk0TgMef2ccre2BlkShhtm1ChgShhtm2Chg
• abnormal neural crest cell apoptosis_Shh<tm1Chg>/Shh<tm2Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0009844I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2AmcNkx25tm1creRjsNkx25Shhtm1ChgNkx25tm1creRjsNkx25Shhtm2Amc
• persistent truncus arteriosis_Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129X1SvJC57BL6JCBAJGtROSA26Sortm1SmoEYFPAmcGtROSA26SorTgWnt1cre11Rth0GtROSA26Sortm1SmoEYFPAmcTgWnt1cre11RthGtROSA26Sor
• abnormal cardiac outflow tract development_Shh<tm1Chg>/Shh<tm2Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0006126I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2AmcNkx25tm1creRjsNkx25Shhtm1ChgNkx25tm1creRjsNkx25Shhtm2Amc
• abnormal artery morphology_Smo<tm2Amc>/Smo<tm2.1Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002191I129S7SvEvBrd129X1SvJSmotm2AmcSmotm21AmcNkx25tm1creRjsNkx25Nkx25Nkx25tm1creRjsSmotm21AmcSmotm2Amc
• embryonic lethality during organogenesis, incomplete penetrance_Gt(ROSA)26Sor<tm1(Smo/EYFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011108I129X1SvJC57BL6JCBAJGtROSA26Sortm1SmoEYFPAmcGtROSA26SorTgWnt1cre11Rth0GtROSA26Sortm1SmoEYFPAmcTgWnt1cre11RthGtROSA26Sor
• persistent truncus arteriosis_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002633I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• abnormal neural crest cell migration_Smo<tm2Amc>/Smo<tm2.1Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002950I129S7SvEvBrd129X1SvJSmotm2AmcSmotm21AmcNkx25tm1creRjsNkx25Nkx25Nkx25tm1creRjsSmotm21AmcSmotm2Amc
• abnormal neural crest cell migration_Shh<tm1Chg>/Shh<tm2Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002950I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2AmcNkx25tm1creRjsNkx25Shhtm1ChgNkx25tm1creRjsNkx25Shhtm2Amc
• abnormal neural crest cell apoptosis_Smo<tm2Amc>/Smo<tm2.1Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0009844I129S7SvEvBrd129X1SvJSmotm2AmcSmotm21AmcNkx25tm1creRjsNkx25Nkx25Nkx25tm1creRjsSmotm21AmcSmotm2Amc
• abnormal artery morphology_Shh<tm1Chg>/Shh<tm2Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002191I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2AmcNkx25tm1creRjsNkx25Shhtm1ChgNkx25tm1creRjsNkx25Shhtm2Amc
• abnormal artery morphology_Shh<tm1Chg>/Shh<tm2Chg>,Tg(Mef2c-cre)2Blk/0
  http://metadb.riken.jp/0002191I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2ChgTgMef2ccre2Blk0TgMef2ccre2BlkShhtm1ChgShhtm2Chg
• abnormal cardiovascular development_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Mpz-cre)94Imeg/0
  http://metadb.riken.jp/0002925I129X1SvJSmotm2AmcSmotm21AmcTgMpzcre94Imeg0Smotm2AmcTgMpzcre94ImegSmotm21Amc
• persistent truncus arteriosis_Shh<tm1Chg>/Shh<tm2Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002633I129S1Sv129S7SvEvBrd129X1SvJShhtm1ChgShhtm2AmcNkx25tm1creRjsNkx25Shhtm1ChgNkx25tm1creRjsNkx25Shhtm2Amc
• abnormal cardiac outflow tract development_Smo<tm2Amc>/Smo<tm2.1Amc>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0006126I129X1SvJC57BL6JCBAJSmotm2AmcSmotm21AmcTgWnt1cre11Rth0Smotm21AmcSmotm2AmcTgWnt1cre11Rth
• persistent truncus arteriosis_Smo<tm2Amc>/Smo<tm2.1Amc>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>
  http://metadb.riken.jp/0002633I129S7SvEvBrd129X1SvJSmotm2AmcSmotm21AmcNkx25tm1creRjsNkx25Nkx25Nkx25tm1creRjsSmotm21AmcSmotm2Amc

class

http://purl.org/net/cito/citesAsAuthority

• Smo<tm2.1Amc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834775