Gema. Medina-Gomez, et.al., PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism., PLoS genetics, 2007, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/17465682

Gema. Medina-Gomez, et.al., PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism., PLoS genetics, 2007, 3

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal insulin secretion_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0003564I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• abnormal lipid homeostasis_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0002118I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• hypoactivity_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001402I129SvC57BL6LepobLepobLepob
• increased urine glucose level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001759I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased body weight_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001260I129SvC57BL6LepobLepobLepob
• abnormal lipid level_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001547I129SvC57BL6LepobLepobLepob
• polyphagia_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001433I129SvC57BL6LepobLepobLepob
• hypoactivity_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001402I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• abnormal skeletal muscle morphology_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0000759I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• hyperglycemia_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001559I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased circulating insulin level_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0002079I129SvC57BL6LepobLepobLepob
• decreased adiponectin level_Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0004893I129SvC57BL6Ppargtm2AvpPpargtm2AvpPpargtm2Avp
• decreased adiponectin level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0004893I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• abnormal glucose homeostasis_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0002078I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased circulating triglyceride level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001552I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• decreased liver triglyceride level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0009356I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• insulin resistance_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005331I129SvC57BL6LepobLepobLepob
• abnormal liver morphology_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0000598I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• polyphagia_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001433I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• insulin resistance_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005331I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• abnormal pancreatic islet morphology_Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005215I129SvC57BL6Ppargtm2AvpPpargtm2AvpPpargtm2Avp
• oxidative stress_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0003674I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased pancreatic islet number_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0009167I129SvC57BL6LepobLepobLepob
• increased percent body fat/body weight_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005458I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased insulin secretion_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0003058I129SvC57BL6LepobLepobLepob
• increased circulating glucose level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005559I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased fluid intake_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0011941I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• decreased circulating insulin level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0002727I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• enlarged pancreatic islets_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0009171I129SvC57BL6LepobLepobLepob
• abnormal fat cell morphology_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0009115I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• decreased respiratory quotient_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0010379I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• hepatic steatosis_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0002628I129SvC57BL6LepobLepobLepob
• abnormal locomotor behavior_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001392I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• decreased triglyceride level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005318I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• abnormal pancreatic islet morphology_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0005215I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased circulating free fatty acid level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0001554I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• disorganized pancreatic islets_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0009254I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• increased percent body fat/body weight_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005458I129SvC57BL6LepobLepobLepob
• abnormal pancreatic islet morphology_Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005215I129SvC57BL6LepobLepobLepob
• increased circulating insulin level_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0002079I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob
• hepatic steatosis_Lep<ob>/Lep<ob>,Pparg<tm2Avp>/Pparg<tm2Avp>
  http://metadb.riken.jp/0002628I129SvC57BL6LepobLepobPpargtm2AvpPpargtm2AvpPpargtm2AvpLepob

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased percent body fat/body weight in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010719
• increased pancreatic islet number in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1006446
• enlarged pancreatic islets in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010722
• increased insulin secretion in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010712
• hepatic steatosis in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1006376
• hypoactivity in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1010705
• abnormal lipid level in RBRC03708
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1006355