Nadine. Dragin, et.al., Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line., Biochemical and biophysical research communications, 2007, 359

http://rdf.ncbi.nlm.nih.gov/pubmed/17560947

Nadine. Dragin, et.al., Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line., Biochemical and biophysical research communications, 2007, 359

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3721229
• Cyp1a2<tm3Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3722076

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged liver_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000599I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased circulating aspartate transaminase level_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0005343I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• small thymus_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000706I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• small spleen_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000692I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• decreased leukocyte cell number_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000221I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased circulating aspartate transaminase level_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/0005343B6129Del9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11Dwn
• small spleen_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/0000692B6129Del9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11Dwn
• increased circulating alanine transaminase level_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0002941I129P2OlaHsdC57BL6Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• enlarged liver_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn,Tg(CYP1A1,CYP1A2)1Dwn/Tg(CYP1A1,CYP1A2)1Dwn
  http://metadb.riken.jp/0000599B6CgDel9Cyp1a2Cyp1a11DwnTgCYP1A1CYP1A21DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnTgCYP1A1CYP1A21DwnTgCYP1A1CYP1A21DwnDel9Cyp1a2Cyp1a11DwnTgCYP1A1CYP1A21Dwn
• small thymus_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/0000706B6129Del9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11Dwn
• decreased leukocyte cell number_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/0000221B6129Del9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11Dwn
• increased circulating alanine transaminase level_Del(9Cyp1a2-Cyp1a1)1Dwn/Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/0002941B6129Del9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11DwnDel9Cyp1a2Cyp1a11Dwn

class

http://purl.org/net/cito/citesAsAuthority

• Del(9Cyp1a2-Cyp1a1)1Dwn
  http://metadb.riken.jp/db/mgi_rdf/MGI:3721229
• Cyp1a2<tm3Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3722076