Lily I. Pao, et.al., B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity., Immunity, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17600736

Lily I. Pao, et.al., B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity., Immunity, 2007, 27

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn6<tm1Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3719625

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased susceptibility to systemic lupus erythematosus_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0004801I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• abnormal lymph organ size_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0002221I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• abnormal humoral immune response_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0001800I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased macrophage cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0005425I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased B-1a cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0008167I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• decreased marginal zone B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0008182I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased granulocyte number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0000322I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased plasma cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0008097I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• abnormal leukocyte cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0000217I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• decreased follicular B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0008174I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased T cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0005015I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• enlarged spleen_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• decreased B cell proliferation_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0005093I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• enlarged lymph nodes_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0000702I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• abnormal immune system physiology_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0001790I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn
• increased B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Ptpn6<tm1Rsky>/Ptpn6<tm1Rsky>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Ptpn6tm1RskyPtpn6tm1RskyPtpn6tm1RskyCd19Cd19tm1creCgn

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn6<tm1Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3719625