Tomoki. Nakamura, et.al., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome., The Journal of clinical investigation, 2007, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/17641779

Tomoki. Nakamura, et.al., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome., The Journal of clinical investigation, 2007, 117

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Myh6-Ptpn11*Q79R)197Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822133
• Tg(Myh6-Ptpn11)75Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822134
• Tg(Myh7-Ptpn11*Q79R)11Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822132
• Tg(Myh7-Ptpn11)294Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822135

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cardiovascular system physiology_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0001544FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• dilated heart ventricle_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0008022FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• ventricular septal defect_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0010402FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• increased lung weight_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0005630FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• decreased cardiac muscle contractility_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0005140FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• abnormal interventricular groove morphology_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0004032FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• increased heart weight_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0002833FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• thick ventricular wall_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0002953FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• premature death_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0002083FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• dilated heart atrium_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0003140FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• ventricular cardiomyopathy_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0002952FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns
• abnormal atrial thrombosis_Tg(Myh7-Ptpn11*Q79R)11Rbns/0
  http://metadb.riken.jp/0001855FVBCgTgMyh7Ptpn11Q79R11RbnsTgMyh7Ptpn11Q79R11Rbns0TgMyh7Ptpn11Q79R11Rbns

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Myh6-Ptpn11*Q79R)197Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822133
• Tg(Myh6-Ptpn11)75Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822134
• Tg(Myh7-Ptpn11*Q79R)11Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822132
• Tg(Myh7-Ptpn11)294Rbns
  http://metadb.riken.jp/db/mgi_rdf/MGI:3822135