Xin. Wang, et.al., Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death., Molecular and cellular biology, 2007, 27

http://rdf.ncbi.nlm.nih.gov/pubmed/17875933

Xin. Wang, et.al., Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death., Molecular and cellular biology, 2007, 27

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Map2k4<tm1Ctr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3769117

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• ataxia_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001393IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• abnormal neuron differentiation_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0009937IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• postnatal growth retardation_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001732IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• postnatal lethality, complete penetrance_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0011085IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• abnormal Purkinje cell morphology_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0000877IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• decreased anterior commissure size_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0008226IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• decreased body weight_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001262IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• impaired coordination_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001405IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• impaired righting response_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001523IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• impaired coordination_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(ACTA1-cre)1Mll/?
  http://metadb.riken.jp/0001405IC57BL6Map2k4tm1CtrMap2k4tm1CtrTgACTA1cre1MllTgACTA1cre1MllMap2k4tm1Ctr
• abnormal cerebellar granule layer morphology_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0000886IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• decreased corpus callosum size_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0000781IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• abnormal cerebellar Purkinje cell layer_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0000875IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• tremors_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0000745IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr
• no abnormal phenotype detected_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>
  http://metadb.riken.jp/0002169IC57BL6Map2k4tm1CtrMap2k4tm1CtrMap2k4tm1Ctr
• abnormal gait_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Tg(Nes-cre)1Kln/?
  http://metadb.riken.jp/0001406IC57BL6SJLMap2k4tm1CtrMap2k4tm1CtrTgNescre1KlnTgNescre1KlnMap2k4tm1Ctr

class

http://purl.org/net/cito/citesAsAuthority

• Map2k4<tm1Ctr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3769117

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD41431
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41431