Shigehisa. Yanagi, et.al., Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice., The Journal of clinical investigation, 2007, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/17909629

Shigehisa. Yanagi, et.al., Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice., The Journal of clinical investigation, 2007, 117

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pulmonary alveolus epithelial cell morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002273I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• decreased alveolar lamellar body number_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010890I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• neonatal lethality, incomplete penetrance_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0011088I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• acidosis_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0003031I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• small lung saccule_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010827I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• abnormal lung development_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001176I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• bronchiolar epithelial hyperplasia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010910I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• cyanosis_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001575I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• hypoxia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0005039I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• abnormal alveolocapillary membrane morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002324I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• increased mesenchymal cell proliferation involved in lung development_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0011147I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• abnormal lung saccule morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010825I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• decreased surfactant secretion_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010993I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• pulmonary hyperplasia_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0004202I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• abnormal type I pneumocyte morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002274I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• respiratory failure_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001953I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• increased lung squamous cell carcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0008717I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• respiratory distress_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0001954I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• abnormal type II pneumocyte morphology_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002275I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• increased incidence of tumors by chemical induction_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0004499I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• increased bronchioalveolar stem cell number_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0010829I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• increased lung adenocarcinoma incidence_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0002027I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak
• decreased survivor rate_Pten<tm2Mak>/Pten<tm2Mak>,Tg(SFTPC-rtTA)5Jaw/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0008770I129129P2OlaHsdC57BL6C57BL6JPtentm2MakPtentm2MakTgSFTPCrtTA5Jaw0TgtetOcre1Jaw0TgSFTPCrtTA5JawTgtetOcre1JawPtentm2Mak