Fernando D. Camargo, et.al., YAP1 increases organ size and expands undifferentiated progenitor cells., Current biology : CB, 2007, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/17980593

Fernando D. Camargo, et.al., YAP1 increases organ size and expands undifferentiated progenitor cells., Current biology : CB, 2007, 17

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-YAP1*)Fcam>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316453
• Tg(Cebpb-tTA)#Bjd
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316471

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased cell proliferation_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000351I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• abnormal intestinal epithelium morphology_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000488I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• enlarged liver_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0000599I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• abnormal hepatocyte morphology_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0000607I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• thick skin_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001200I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• premature death_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
他11件を見る
• increased liver weight_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0002981I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• abnormal intestinal goblet cell morphology_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003449I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• enlarged pancreas_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003450I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• increased hepatocyte proliferation_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0003893I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• liver hyperplasia_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0005141I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• abnormal enterocyte proliferation_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008883I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• decreased hepatocyte apoptosis_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Tg(Cebpb-tTA)#Bjd/0
  http://metadb.riken.jp/0008891I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd0Col1a1tm1tetOYAP1FcamCol1a1TgCebpbtTABjd
• increased pancreatic acinar cell number_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009159I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• decreased alkaline phosphatase activity_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011585I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• pancreatic acinar-to-ductal metaplasia_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0013221I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae
• absent Paneth cells_Col1a1<tm1(tetO-YAP1*)Fcam>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0014076I129S4SvJaeC57BL6Col1a1tm1tetOYAP1FcamCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorCol1a1tm1tetOYAP1FcamGtROSA26SorCol1a1GtROSA26Sortm1rtTAM2Jae

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(tetO-YAP1*)Fcam>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316453
• Tg(Cebpb-tTA)#Bjd
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316471